AOC3 Antikörper

Produktnummer ABIN2192061

Produktdetails anti-AOC3 Antikörper

Target: AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AOC3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Kreuzreaktivität (Details): Cross reactivity: Rat : Yes

Sterilität: 0.2 μm filtered

Klon: 174-5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: For immunohistochemistry and flow cytometry, dilutions to be used depend on detection system chemistry, , applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Ax cells stably transfected with VAP-1 cDNA. (Ref. 1) VAP control Negative Mock transfected Ax cells. (Ref. 1) control

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Referenzen für anti-AOC3 Antikörper (ABIN2192061)

Autio, Ujula, Luoto, Salomäki, Jalkanen, Roivainen: "PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG." in: European journal of nuclear medicine and molecular imaging, Vol. 37, Issue 10, pp. 1918-25, (2010) (PubMed).

Martelius, Salaspuro, Salmi, Krogerus, Höckerstedt, Jalkanen, Lautenschlager: "Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection." in: The American journal of pathology, Vol. 165, Issue 6, pp. 1993-2001, (2004) (PubMed).

Details zu AOC3

Target: AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))

Andere Bezeichnung: Vascular Adhesion Protein-1 (AOC3 Produkte)

Synonyme: HPAO antikoerper, SSAO antikoerper, VAP-1 antikoerper, VAP1 antikoerper, aoc2 antikoerper, BOLAO antikoerper, amine oxidase, copper containing 3 antikoerper, amine oxidase, copper containing 3 L homeolog antikoerper, AOC3 antikoerper, aoc3.L antikoerper, Aoc3 antikoerper

Hintergrund: The monoclonal antibody 174-5 recognises human Vascular Adhesion Protein-1 (VAP-1), which is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part. A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia. VAP-1 is present in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end- products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. Elevated sVAP- 1serum levels have been described in several inflammatory diseases as well as colorectal cancer. Moreover, diminished insulin secretion appears to increase the concentration of soluble VAP-1 in plasma. Therefore, VAP-1 might be an interesting diagnostic marker as well therapeutic target for modulating inflammation.The monoclonal antibody 174-5 has been shown to cross-react with rat VAP- 1 and to inhibit lymphocyte infiltration in rat liver allograft rejection. Aliases membrane primary amine oxidase, AOC3, SSAO Immunogen Purified vessels from human peripheral lymph nodes (ref 1)

Pathways: Feeding Behaviour