Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Tamalin/GRASP Antikörper

GRASP Reaktivität: Maus WB, ELISA, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN233820
  • Target Alle Tamalin/GRASP (GRASP) Antikörper anzeigen
    Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
    Reaktivität
    • 17
    • 16
    • 15
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 18
    Kaninchen
    Klonalität
    • 18
    Polyklonal
    Konjugat
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Tamalin/GRASP Antikörper ist unkonjugiert
    Applikation
    • 9
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of mouse Tamalin protein.
    Isotyp
    IgG
    Top Product
    Discover our top product GRASP Primärantikörper
  • Applikationshinweise
    This affinity purified antibody has been tested for use in ELISA, western blotting, and immunoprecipitation.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 42 kDa in size corresponding to Tamalin protein by western blotting in the appropriate cell lysate or extract.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.03 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Kimura, Kitano, Nakajima, Nakanishi: "Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 9, Issue 7, pp. 631-40, (2004) (PubMed).

    Hirose, Kitano, Nakajima, Moriyoshi, Yanagi, Yamamura, Muto, Jingami, Nakanishi: "Phosphorylation and recruitment of Syk by immunoreceptor tyrosine-based activation motif-based phosphorylation of tamalin." in: The Journal of biological chemistry, Vol. 279, Issue 31, pp. 32308-15, (2004) (PubMed).

    Kitano, Nishida, Itsukaichi, Minami, Ogawa, Hirano, Mori, Nakanishi: "Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel." in: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 25101-8, (2003) (PubMed).

    Kitano, Kimura, Yamazaki, Soda, Shigemoto, Nakajima, Nakanishi: "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 4, pp. 1280-9, (2002) (PubMed).

  • Target
    Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
    Andere Bezeichnung
    Tamalin (GRASP Produkte)
    Synonyme
    GRASP antikoerper, tamalin antikoerper, TAMALIN antikoerper, general receptor for phosphoinositides 1 associated scaffold protein antikoerper, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein antikoerper, GRASP antikoerper, grasp antikoerper, Grasp antikoerper
    Hintergrund
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Tamalin, also named General receptor for phosphoinositides 1-associated scaffold protein (GRASP) is a PDZ (post-synaptic density protein/Drosophila disc large tumor suppressor/zo-1) domain-containing protein that interacts with group 1 metabotropic glutamate receptors (mGluRs).  The PDZ domain-containing amino-terminal half of Tamalin binds directly to the class I PDZ-binding motif of group 1 mGluRs.  The carboxyl-terminal half of Tamalin binds to cytohesins, which are guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins.  Tamalin forms a protein complex with group 1 mGluRs at the post-synaptic site of specific neuronal cells and serves as a key scaffold protein that links a complex formation between mGluR1a and cytohesins.  It is reported that Tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.
    Synonyms: DXImx47e antibody, GRASP 1 antibody, GRIP 1 associated protein 1 antibody, GRIP associated protein 1 antibody, GRIP1 associated protein 1 antibody, GRIPAP 1 antibody, General receptor for phosphoinositides 1-associated scaffold protein
    Gen-ID
    56149, 103472019
    UniProt
    Q9JJA9
Sie sind hier:
Kundenservice