PPP1R13B Antikörper (Internal Region)

Produktnummer ABIN233830

Produktdetails anti-PPP1R13B Antikörper

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP1R13B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 120 kDa in size corresponding to ASPP1 by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu PPP1R13B

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Andere Bezeichnung: ASPP1 (PPP1R13B Produkte)

Synonyme: ASPP1 antikoerper, p53BP2-like antikoerper, p85 antikoerper, AI449786 antikoerper, AW545810 antikoerper, Tp53bp2 antikoerper, Trp53bp2 antikoerper, protein phosphatase 1 regulatory subunit 13B antikoerper, protein phosphatase 1, regulatory subunit 13B antikoerper, protein phosphatase 1 regulatory subunit 13B L homeolog antikoerper, protein phosphatase 1, regulatory subunit 13Bb antikoerper, protein phosphatase 1, regulatory (inhibitor) subunit 13B antikoerper, PPP1R13B antikoerper, Ppp1r13b antikoerper, ppp1r13b.L antikoerper, ppp1r13bb antikoerper, ppp1r13b antikoerper

Hintergrund: ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
Synonyms: p53BP2 like antibody, p85 antibody, PPP1R13B antibody

Gen-ID: 23368, 121114287

UniProt: Q62415

Pathways: p53 Signalweg