PIN1 Antikörper (Internal Region)

Produktnummer ABIN233831

Produktdetails anti-PIN1 Antikörper

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Hund, Schaf, Affe

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human Pin1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 18 kDa in size corresponding to Pin1 by western blotting in the appropriate cell lysate or extract.  Lysates from 3T3, Jurkat, 293 or HeLa cells, as well as HeLa nuclear extract, are recommended for use as positive controls.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.2 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-PIN1 Antikörper (ABIN233831)

Lucchetti, Caligiuri, Toffoli, Giordano, Rizzolio: "The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer." in: PLoS ONE, Vol. 8, Issue 2, pp. e55355, (2013) (PubMed).

La Montagna, Caligiuri, Maranta, Lucchetti, Esposito, Paggi, Toffoli, Rizzolio, Giordano: "Androgen receptor serine 81 mediates Pin1 interaction and activity." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 18, pp. 3415-20, (2013) (PubMed).

Rizzolio, Lucchetti, Caligiuri, Marchesi, Caputo, Klein-Szanto, Bagella, Castronovo, Giordano: "Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1." in: Cell death and differentiation, Vol. 19, Issue 7, pp. 1152-61, (2012) (PubMed).

Details zu PIN1

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Andere Bezeichnung: PIN1 (PIN1 Produkte)

Synonyme: DOD antikoerper, UBL5 antikoerper, dod antikoerper, ubl5 antikoerper, pin1 antikoerper, pin1a antikoerper, 0610025L01Rik antikoerper, D9Bwg1161e antikoerper, pin1b antikoerper, zgc:73206 antikoerper, PPIase pin1 antikoerper, MdPin1 antikoerper, Pin1 antikoerper, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 antikoerper, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog antikoerper, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 antikoerper, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog antikoerper, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antikoerper, peptidyl-prolyl cis-trans isomerase Pin1 antikoerper, PIN1 antikoerper, Pin1 antikoerper, pin1 antikoerper, pin1.S antikoerper, pin1.L antikoerper, ppiD antikoerper, PITG_11123 antikoerper, LOC103419188 antikoerper

Hintergrund: Pin1 (peptidylprolyl cis/trans isomerase NIMA-interacting 1 protein) is an essential peptidylprolyl isomerase that regulates mitosis, presumably by interacting with NIMA and attenuating its mitosis-promoting activity.  Pin1 displays a preference for an acidic residue N-terminal to the isomerized proline bond and also catalyzes pSer/Thr-Pro cis/trans isomerizations.  Pin1 shows a nuclear localization.
Synonyms: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, Prolyl isomerase antibody, Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody, Protein NIMA interacting 1 antibody, Rotamase Pin1 antibody, UBL 5 antibody

Gen-ID: 5300, 5453898

UniProt: Q13526