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Calreticulin Antikörper
CALR
Reaktivität: Human, Maus, Ratte
WB, ELISA, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2428195
Produktdetails anti-Calreticulin Antikörper
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Target
Alle Calreticulin (CALR) Antikörper anzeigen
Calreticulin (CALR)
Reaktivität
Alle Reaktivitäten für Calreticulin Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für Calreticulin Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für Calreticulin Antikörper
Polyklonal
Konjugat
Alle Konjugate für Calreticulin Antikörper
Dieser Calreticulin Antikörper ist unkonjugiert
Applikation
Alle Applikationen für Calreticulin Antikörper
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Aufreinigung
Affinity purification
Immunogen
Recombinant protein of human CALR
Isotyp
IgG
Top Product
Discover our top product CALR Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
WB 1:1000-1:5000, IHC 1:50-1:200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
0.2 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Konservierungsmittel
Sodium azide
Handhabung
Avoid freeze / thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C. Avoid freeze / thaw cycles.
Details zu Calreticulin
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Target
Calreticulin (CALR)
Andere Bezeichnung
CALR (CALR Produkte )
Synonyme
CRT antikoerper, RO antikoerper, SSA antikoerper, cC1qR antikoerper, crc antikoerper, crt antikoerper, Calregulin antikoerper, CG9429 antikoerper, Clr antikoerper, Dmel\\CG9429 antikoerper, anon-EST:Liang-2.11 antikoerper, anon-EST:Liang-2.17 antikoerper, anon-EST:fe3D7 antikoerper, clone 2.11 antikoerper, clone 2.17 antikoerper, eth antikoerper, potp antikoerper, cc1qr antikoerper, ssa antikoerper, NV19007 antikoerper, CRP55 antikoerper, ERp60 antikoerper, HACBP antikoerper, CHOT1 antikoerper, CHT1 antikoerper, CT1 antikoerper, AA589632 antikoerper, CRTR antikoerper, Creat antikoerper, CCDS1 antikoerper, calrl2 antikoerper, fc66d10 antikoerper, wu:fc66d10 antikoerper, wu:fj50c03 antikoerper, zgc:66153 antikoerper, calreticulin antikoerper, calreticulin L homeolog antikoerper, Calreticulin antikoerper, putative calreticulin antikoerper, solute carrier family 6 member 8 antikoerper, solute carrier family 6 (neurotransmitter transporter, creatine), member 8 antikoerper, CALR antikoerper, calr.L antikoerper, Crt antikoerper, crt antikoerper, CRT antikoerper, Calr antikoerper, calr antikoerper, LMJF_31_2600 antikoerper, Crc antikoerper, Slc6a8 antikoerper, SLC6A8 antikoerper, LOC8269812 antikoerper
Hintergrund
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.
Molekulargewicht
Calculated MW: 48 kDa
Pathways
Retinoic Acid Receptor Signaling Pathway , Intracellular Steroid Hormone Receptor Signaling Pathway , Regulation of Intracellular Steroid Hormone Receptor Signaling , Nuclear Hormone Receptor Binding , ER-Nucleus Signaling , Unfolded Protein Response
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