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CD40 Antikörper (Extracellular Domain)

CD40 Reaktivität: Human FACS, IHC, St Wirt: Maus Monoclonal 5C3 unconjugated
Produktnummer ABIN2451933
  • Target Alle CD40 Antikörper anzeigen
    CD40
    Bindungsspezifität
    • 17
    • 16
    • 15
    • 14
    • 13
    • 12
    • 9
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reaktivität
    • 189
    • 114
    • 22
    • 20
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 105
    • 99
    • 55
    • 8
    • 2
    • 1
    • 1
    • 1
    Maus
    Klonalität
    • 175
    • 90
    • 5
    Monoklonal
    Konjugat
    • 123
    • 26
    • 22
    • 18
    • 14
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD40 Antikörper ist unkonjugiert
    Applikation
    • 155
    • 97
    • 62
    • 50
    • 32
    • 32
    • 20
    • 19
    • 16
    • 14
    • 13
    • 12
    • 8
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC), Stimulation (St)
    Aufreinigung
    Purified from serum-free medium by salting-out and ion-exchange chromatography under mild conditions.
    Sterilität
    Sterile filtered
    Immunogen
    Recombinant extracellular domain of CD40 Product, Purified from serum-free medium by salting-out and ion-exchange chromatography under mild conditions.
    Klon
    5C3
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product CD40 Primärantikörper
  • Applikationshinweise
    1. Flowcytometry
    2. Immunohistochemistry (acetone or zinc-fixed or frozen section, indirect immuno-staining)
    3. Stimulation of proliferation of B cell and dendritic cells. Enhancement of proinflamentory cytokine production in human monocytes,such as TNF-a,IL-6 and IL-8
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol. Azide- and carrier protein-free.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C
  • Ishida, Kumanogoh, Suzuki, Akahani, Noda, Kikutani: "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses." in: International immunology, Vol. 15, Issue 8, pp. 1027-34, (2003) (PubMed).

    Yasui, Muraoka, Takaoka-Shichijo, Ishida, Takegahara, Uchida, Kumanogoh, Suematsu, Suzuki, Kikutani: "Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals." in: International immunology, Vol. 14, Issue 3, pp. 319-29, (2002) (PubMed).

    Inui, Kaisho, Kikutani, Stamenkovic, Seed, Clark, Kishimoto: "Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40." in: European journal of immunology, Vol. 20, Issue 8, pp. 1747-53, (1990) (PubMed).

  • Target
    CD40
    Andere Bezeichnung
    CD40 (CD40 Produkte)
    Synonyme
    Bp50 antikoerper, CDW40 antikoerper, TNFRSF5 antikoerper, p50 antikoerper, AI326936 antikoerper, GP39 antikoerper, HIGM1 antikoerper, IGM antikoerper, IMD3 antikoerper, T-BAM antikoerper, TRAP antikoerper, Tnfrsf5 antikoerper, TNFSF5 antikoerper, CD40 molecule antikoerper, CD40 antigen antikoerper, CD40 antikoerper, Cd40 antikoerper
    Hintergrund
    CD40 is a 45-50- kDa glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. CD40 is specifically expressed on the surface of B cells and specialized antigen-presenting cells such as dendritic cells and macrophages. CD40 interacts with the CD40 ligand (CD154) which is found primarily on T cells, playing a role in both humoral and cell-mediated immune responses. Activation of CD40 on B cells by CD40 ligand causes B cell proliferation, differentiation, immunoglobulin isotype switching, germinal center formation, and stimulation of the humoral memory response. CD40 has been found to mediate a broad variety of immune and inflammatory responses. Within the cell, the CD40 Molecule acts as a transmembrane signal transducer that leads to activation of intracellular kinases and transcription factors.
    UniProt
    P25942
    Pathways
    NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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