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HBEGF Antikörper (EGF Like Domain) (Biotin)

HBEGF Reaktivität: Human WB, ELISA, IP, ICC, IF Wirt: Maus Monoclonal 4G10 Biotin
Produktnummer ABIN2451994
  • Target Alle HBEGF Antikörper anzeigen
    HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
    Bindungsspezifität
    • 15
    • 15
    • 14
    • 8
    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    EGF Like Domain
    Reaktivität
    • 74
    • 20
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 69
    • 8
    Maus
    Klonalität
    • 67
    • 9
    • 1
    Monoklonal
    Konjugat
    • 26
    • 9
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser HBEGF Antikörper ist konjugiert mit Biotin
    Applikation
    • 33
    • 28
    • 26
    • 15
    • 13
    • 9
    • 7
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Kreuzreaktivität (Details)
    Does not react with mouse.
    Produktmerkmale
    biotin/IgG = 7.5
    Aufreinigung
    Purified
    Sterilität
    Sterile filtered
    Immunogen
    Recombinant human HB-EGF ectodomain expressed in SF21 cell
    Klon
    4G10
    Isotyp
    IgG1
    Top Product
    Discover our top product HBEGF Primärantikörper
  • Applikationshinweise
    1) Western blotting: 0. 2~1 g/mL
    2) Immunoprecipitation: 2 g/mL
    3) Indirect immuno-fluorescence staining: 5~10 g/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    -20 C (For long term storage: -80 C)
  • Miyamoto, Hirata, Yamazaki, Kageyama, Hasuwa, Mizushima, Tanaka, Yagi, Sonoda, Kai, Kanoh, Nakano, Mekada: "Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy." in: Cancer research, Vol. 64, Issue 16, pp. 5720-7, (2004) (PubMed).

    Prenzel, Zwick, Daub, Leserer, Abraham, Wallasch, Ullrich: "EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF." in: Nature, Vol. 402, Issue 6764, pp. 884-8, (2000) (PubMed).

    Iwamoto, Higashiyama, Mitamura, Taniguchi, Klagsbrun, Mekada et al.: "Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin ..." in: The EMBO journal, Vol. 13, Issue 10, pp. 2322-30, (1994) (PubMed).

    Higashiyama, Abraham, Miller, Fiddes, Klagsbrun: "A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF." in: Science (New York, N.Y.), Vol. 251, Issue 4996, pp. 936-9, (1991) (PubMed).

  • Target
    HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
    Andere Bezeichnung
    HB-EGF (HBEGF Produkte)
    Synonyme
    hbegf antikoerper, zgc:165443 antikoerper, HBEGF antikoerper, zgc:175091 antikoerper, DTR antikoerper, DTS antikoerper, DTSF antikoerper, HEGFL antikoerper, Dtr antikoerper, GFHB antikoerper, Hb-egf antikoerper, Hegfl antikoerper, AW047313 antikoerper, Dts antikoerper, HB-EGF antikoerper, heparin-binding EGF-like growth factor b antikoerper, heparin binding EGF like growth factor antikoerper, Heparin-binding EGF-like growth factor antikoerper, heparin-binding EGF-like growth factor a antikoerper, heparin-binding EGF-like growth factor antikoerper, hbegfb antikoerper, HBEGF antikoerper, hbegf antikoerper, hbegfa antikoerper, Hbegf antikoerper
    Hintergrund
    Background: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is synthesized as a membrane-anchored precursor that is proteolytically cleaved to release the soluble mature growth factor, HB-EGF. The former functions as juxtacrine and the latter as paracrine growth factor. Soluble HB-EGF shows several forms in Western blotting with apparent molecular weights 19~27 kDa due to heterogeneous O-glycosylation and N-terminal truncation. HB-EGF activates EGFR and ErbB4 and promotes the development in many tissues. In human ProHB-EGF is the cellular receptor for diphtheria toxin. Non-toxic mutant of diphtheria toxin, CRM197, inhibits HB-EGF function. As HB-EGF level is elevated in most ovarian cancer, CRM197 is being tested as an anticancer drug. The hybridoma clone 4G10 was established and characterized in the laboratory of Prof. E. Mekada of Osaka University, who is a leading scientist in this field.
    UniProt
    Q99075
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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