NUP98 Antikörper (GLFG Motif, N-Term)

Produktnummer ABIN2452064

Produktdetails anti-NUP98 Antikörper

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Bindungsspezifität: GLFG Motif, N-Term

Reaktivität: Human, Maus, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Tetrahymena

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NUP98 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität (Details): Not tested in other species.

Aufreinigung: Purified

Sterilität: Sterile filtered

Immunogen: Synthetic peptides containing conserved N-terminal sequence, GLFG, of Nup98 protein of Tetrahymena thermophila.

Klon: 21A10

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: 1) Western blotting: S. cerevisiae, S. pombe. Not suitable for human. Clone 13C2 is recommended for WB in human Tetrahymena and yeasts.
2) Most suitable for Immunofluorescence staining / Immunocytochemistry for human, mouse, Tetrahymena, S. cerevisiae, S. pombe.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol. Azide- and carrier protein-free.

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Upon arrival centrifuge briefly and store at -20 C.

Referenzen für anti-NUP98 Antikörper (ABIN2452064)

Iwamoto, Asakawa, Ohtsuki, Osakada, Koujin, Hiraoka, Haraguchi: "Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans." in: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 32, Issue 2, pp. 81-90, (2013) (PubMed).

Iwamoto, Asakawa, Hiraoka, Haraguchi: "Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 7, pp. 661-9, (2010) (PubMed).

Details zu NUP98

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Andere Bezeichnung: Nup98 (NUP98 Produkte)

Synonyme: CG10198 antikoerper, CG10201 antikoerper, Dmel\\CG10198 antikoerper, Nup 96 antikoerper, Nup 98 antikoerper, Nup-98 antikoerper, Nup96 antikoerper, Nup98 antikoerper, Nup98-Nup96 antikoerper, Nup98/96 antikoerper, l(3)95BCd antikoerper, nup145 antikoerper, nup98-96 antikoerper, GB12688 antikoerper, NUP98 antikoerper, 4732457F17 antikoerper, AI849286 antikoerper, im:7151238 antikoerper, zgc:113968 antikoerper, zgc:63593 antikoerper, ADIR2 antikoerper, NUP196 antikoerper, NUP96 antikoerper, Nucleoporin 98-96kD antikoerper, nuclear pore complex protein Nup98-Nup96 antikoerper, nucleoporin 98 antikoerper, nucleoporin 98kDa antikoerper, nucleoporin 98 L homeolog antikoerper, Nup98-96 antikoerper, LOC408335 antikoerper, NUP98 antikoerper, LOC587580 antikoerper, Nup98 antikoerper, nup98 antikoerper, nup98.L antikoerper

Hintergrund: Nucleoporin 98 (Nup98) is a component of nuclear pore complex (NPC), which is a large protein assembly embedded in the nuclear envelope and highly conserved in eukaryotes. It is localized on both nuclear and cytoplasmic side of NPC. This protein contains glycine-leucine-phenylalanine- glycine (GLFG) amino acid repeats and plays a critical role in nuclear trafficking. Nup98 also plays a specific role in the RNA export. In addition, Nup98 plays roles in several important biological events such as gene expression, mitotic checkpoint, and pathogenesis Nup98 gene is fused to a variety of partner genes in human myeloid and T-cell malignancies via chromosomal translocation. In ciliates, a unicellular organism having two functionally distinct nuclei, GLFG-Nup98 is present in one of the nuclei and a distinct Nup98 ortholog is present in the other nucleus, and these different Nup98s participate in a nucleus-selective transport mechanism.

UniProt: P52948

Pathways: Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interaktom