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SUMO2/3 Antikörper (full length)

SUMO2/3 Reaktivität: Human, Maus, Ratte WB, IF, ELISA, IHC (fro) Wirt: Ratte Monoclonal 3H12 unconjugated
Produktnummer ABIN2452139
  • Target Alle SUMO2/3 Produkte
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Bindungsspezifität
    • 16
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length
    Reaktivität
    • 48
    • 13
    • 13
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 38
    • 10
    Ratte
    Klonalität
    • 30
    • 18
    Monoklonal
    Konjugat
    • 14
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SUMO2/3 Antikörper ist unkonjugiert
    Applikation
    • 41
    • 24
    • 14
    • 14
    • 14
    • 13
    • 10
    • 7
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    Specific to SUMO2 and SUMO3 of human, simian, mouse, hamster and rat. Does not react with SUMO1. This antibody recognizes both SUMO2 and SUMO3, but not SUMO1.
    Kreuzreaktivität (Details)
    Not tested for other species
    Aufreinigung
    The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.
    Sterilität
    Sterile filtered
    Immunogen
    Recombinant GST-fused human SUMO3 (full length)
    Klon
    3H12
    Isotyp
    IgG2a kappa
  • Applikationshinweise
    1. Western blotting: 1/1,000
    2. Immunocytochemistry/Immunofluorescence staining: 1/100~1/500
    3. Immunohistochemistry,frozen section: 1/100~1/500
    4. ELISA (Assay dependent concentration)
    Other applications have not been tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS (x1), 50 % glycerol. Azide and carrier free.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Upon arrival centrifuge briefly and store at -20 C.
  • Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

  • Target
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Andere Bezeichnung
    SUMO2/3 (SUMO2/3 Produkte)
    Synonyme
    SUMO2 antikoerper, small ubiquitin-like modifier 2 antikoerper, SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like antikoerper, small ubiquitin-related modifier 2 antikoerper, SUMO2 antikoerper, LOC711990 antikoerper, LOC714892 antikoerper
    Hintergrund
    SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. There are three confirmed SUMO isoforms in human, SUMO1, SUMO2 and SUMO3. SUMO2 and 3 show a high degree of similarity to each other and are distinct from SUMO1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO2/3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, and regulates chromosomal segregation and cellular responses to environmental stress.
    Molekulargewicht
    10,871 Da with 95 AA, 11,637 Da with 103 AA
    UniProt
    P61956, P55854
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