ING3 Antikörper
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- Target Alle ING3 Antikörper anzeigen
- ING3 (Inhibitor of Growth Family, Member 3 (ING3))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ING3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- Antibody is purified by peptide affinity chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ING3.
- Top Product
- Discover our top product ING3 Primärantikörper
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- Applikationshinweise
- ING3 antibody can be used for detection of ING3 by ELISA at 1:312500. ING3 antibody can be used for detection of ING3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Konzentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handhabung
- As with any antibody avoid repeat freeze-thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store ING3 antibody at -20 °C.
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- Target
- ING3 (Inhibitor of Growth Family, Member 3 (ING3))
- Andere Bezeichnung
- ING3 (ING3 Produkte)
- Synonyme
- ING3 antikoerper, Eaf4 antikoerper, ING2 antikoerper, MEAF4 antikoerper, p47ING3 antikoerper, 1300013A07Rik antikoerper, P47ING3 antikoerper, zgc:56327 antikoerper, inhibitor of growth family member 3 antikoerper, inhibitor of growth family, member 3 antikoerper, inhibitor of growth protein 3 antikoerper, inhibitor of growth family member 3 L homeolog antikoerper, ING3 antikoerper, Ing3 antikoerper, CpipJ_CPIJ009396 antikoerper, ing3 antikoerper, ing3.L antikoerper
- Hintergrund
- ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
- Molekulargewicht
- 47 kDa
- Gen-ID
- 54556
- NCBI Accession
- NP_061944
- UniProt
- Q9NXR8
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