COX10 Antikörper
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- Target Alle COX10 Antikörper anzeigen
- COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser COX10 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- Antibody is purified by peptide affinity chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COX10.
- Top Product
- Discover our top product COX10 Primärantikörper
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- Applikationshinweise
- COX10 antibody can be used for detection of COX10 by ELISA at 1:312500. COX10 antibody can be used for detection of COX10 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Konzentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handhabung
- As with any antibody avoid repeat freeze-thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store COX10 antibody at -20 °C.
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- Target
- COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))
- Andere Bezeichnung
- COX10 (COX10 Produkte)
- Synonyme
- 2410004F01Rik antikoerper, AU042636 antikoerper, im:7145568 antikoerper, im:7157205 antikoerper, wu:fb18a03 antikoerper, F4I1.50 antikoerper, F4I1_50 antikoerper, cytochrome c oxidase 10 antikoerper, Cox10 antikoerper, cytochrome c oxidase assembly protein 10 antikoerper, COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor antikoerper, COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor L homeolog antikoerper, COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor antikoerper, cytochrome c oxidase 10 antikoerper, protoheme IX farnesyltransferase, mitochondrial antikoerper, Cox10 antikoerper, cox10 antikoerper, cox10.L antikoerper, COX10 antikoerper, LOC100732273 antikoerper
- Hintergrund
- Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. COX10 is heme A: farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Molekulargewicht
- 49 kDa
- Gen-ID
- 1352
- NCBI Accession
- NP_001294
- UniProt
- Q12887
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