E2F4 Antikörper
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- Target Alle E2F4 Antikörper anzeigen
- E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))
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Reaktivität
- Human, Maus, Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser E2F4 Antikörper ist unkonjugiert
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Applikation
- ELISA, Western Blotting (WB)
- Aufreinigung
- Antibody is purified by peptide affinity chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human E2F4.
- Top Product
- Discover our top product E2F4 Primärantikörper
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- Applikationshinweise
- E2F4 antibody can be used for detection of E2F4 by ELISA at 1:312500. E2F4 antibody can be used for detection of E2F4 by western blot at 2.0/mL.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Konzentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handhabung
- As with any antibody avoid repeat freeze-thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store E2F4 antibody at -20 °C.
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- Target
- E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))
- Andere Bezeichnung
- E2F4 (E2F4 Produkte)
- Synonyme
- E2F-4 antikoerper, 2010111M04Rik antikoerper, AI427446 antikoerper, E2F4 antikoerper, e2f-4 antikoerper, fb72f07 antikoerper, wu:fb72f07 antikoerper, wu:fe05f06 antikoerper, zgc:63815 antikoerper, E2F transcription factor 4 antikoerper, E2F transcription factor 4 S homeolog antikoerper, E2F4 antikoerper, E2f4 antikoerper, e2f4.S antikoerper, e2f4 antikoerper
- Hintergrund
- The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins. It is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It also plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
- Molekulargewicht
- 44 kDa
- Gen-ID
- 1874
- NCBI Accession
- NP_001941
- UniProt
- Q16254
- Pathways
- Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size
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