CHRNB2 Antikörper
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- Target Alle CHRNB2 Antikörper anzeigen
- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CHRNB2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- Antibody is purified by peptide affinity chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHRNB2.
- Top Product
- Discover our top product CHRNB2 Primärantikörper
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- Applikationshinweise
- CHRNB2 antibody can be used for detection of CHRNB2 by ELISA at 1:312500. CHRNB2 antibody can be used for detection of CHRNB2 by western blot at 5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Konzentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handhabung
- As with any antibody avoid repeat freeze-thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store CHRNB2 antibody at -20 °C.
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- Target
- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
- Andere Bezeichnung
- CHRNB2 (CHRNB2 Produkte)
- Synonyme
- EFNL3 antikoerper, nAChRB2 antikoerper, NACHRB2 antikoerper, Acrb-2 antikoerper, Acrb2 antikoerper, C030030P04Rik antikoerper, [b]2-nAchR antikoerper, cholinergic receptor nicotinic beta 2 subunit antikoerper, cholinergic receptor nicotinic beta 2 subunit S homeolog antikoerper, cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) antikoerper, CHRNB2 antikoerper, chrnb2.S antikoerper, Chrnb2 antikoerper
- Hintergrund
- Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.
- Molekulargewicht
- 57 kDa
- Gen-ID
- 1141
- NCBI Accession
- NP_000739
- UniProt
- P17787
- Pathways
- Sensory Perception of Sound, Feeding Behaviour
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