HS3ST5 Antikörper

Produktnummer ABIN2463259

Produktdetails anti-HS3ST5 Antikörper

Target: HS3ST5 (Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 5 (HS3ST5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HS3ST5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HS3ST5.

Anwendungsinformationen

Applikationshinweise: HS3ST5 antibody can be used for detection of HS3ST5 by ELISA at 1:1562500. HS3ST5 antibody can be used for detection of HS3ST5 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store HS3ST5 antibody at -20 °C.

Details zu HS3ST5

Target: HS3ST5 (Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 5 (HS3ST5))

Andere Bezeichnung: HS3ST5 (HS3ST5 Produkte)

Synonyme: 3-OST-5 antikoerper, 3OST5 antikoerper, HS3OST5 antikoerper, NBLA04021 antikoerper, D930005L05Rik antikoerper, Gm1151 antikoerper, Hs3ost5 antikoerper, HS3ST6 antikoerper, HS3ST5 antikoerper, heparan sulfate-glucosamine 3-sulfotransferase 5 antikoerper, heparan sulfate (glucosamine) 3-O-sulfotransferase 5 antikoerper, HS3ST5 antikoerper, Hs3st5 antikoerper, hs3st5 antikoerper

Hintergrund: HS3ST5 is the rate limiting enzyme for synthesis of HSact. It performs the crucial step modification in the biosynthesis of anticoagulant heparan sulfate (HSact) that is to complete the structure of the antithrombin pentasaccharide binding site. HS3ST5 also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).

Molekulargewicht: 40 kDa

Gen-ID: 222537

NCBI Accession: NP_705840

UniProt: Q8IZT8

Pathways: Glycosaminoglycan Metabolic Process