Calcineurin A Antikörper (AA 264-283) (PerCP)

Produktnummer ABIN2481988

Produktdetails anti-Calcineurin A Antikörper (PerCP)

Target: Calcineurin A (CAN)

Bindungsspezifität: AA 264-283

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Calcineurin A Antikörper ist konjugiert mit PerCP

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: Detects ~61 kDa.

Kreuzreaktivität: Hund, Human, Maus, Kaninchen, Ratte

Aufreinigung: Peptide Affinity Purified

Immunogen: Human Calcineurin A peptide (AA 264-283)

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• ICC/IF (1:120)
• IHC (1:100)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN2481988 was sufficient for detection of Calcineurin A in 20 μg of Heat shock Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu Calcineurin A

Target: Calcineurin A (CAN)

Andere Bezeichnung: Calcineurin A (CAN Produkte)

Synonyme: Cna antikoerper, DDBDRAFT_0185021 antikoerper, DDBDRAFT_0217855 antikoerper, DDB_0185021 antikoerper, DDB_0217855 antikoerper, PPP3CC antikoerper, CAN A1/PP2B antikoerper, CG1455 antikoerper, CNA1 antikoerper, Can antikoerper, Cana1 antikoerper, CnA antikoerper, CnnA21EF antikoerper, D14 antikoerper, DmCanA1-100B antikoerper, Dmel\\CG1455 antikoerper, PP2B antikoerper, PP2B 21EF antikoerper, PpD14 antikoerper, canA antikoerper, pMY4 antikoerper, calcineurin A antikoerper, Calcineurin A antikoerper, CaM-dependent protein phosphatase, catalytic subunit antikoerper, protein phosphatase 3 catalytic subunit alpha antikoerper, Calcineurin A1 antikoerper, protein phosphatase 3 catalytic subunit beta antikoerper, Cna antikoerper, NFIA_077970 antikoerper, ACLA_011200 antikoerper, PAS_chr3_0414 antikoerper, canA antikoerper, PPP3CA antikoerper, CanA1 antikoerper, PPP3CB antikoerper

Hintergrund: Calcineurin is a heterodimeric phosphatase protein, also known as calcium-dependent serine-threonine phosphatase. The structure consists of a catalytic subunit alpha, Calcineurin A (57-59KDa) the active site and a Ca2+ binding unit, Calcineurin B (19-20KDa) the regulatory subunit(1). Calcineurin plays a key role in the T-cell response growth and differentiation mechanism, regulating the activation of the Nuclear factor of activated T-cells (NFATc) which are important in the expression of IL-2 genes. Calcineurin has been the target of inhibitors, the novel and structural immune-suppressants antifungal drugs(2). Genetic studies in yeast and fungi established the molecular basis of the inhibition mechanism by cyclosporine A and FK506 (3).

Gen-ID: 5530

UniProt: Q08209