Piccolo Antikörper (HRP)
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- Target Alle Piccolo (PIC) Produkte
- Piccolo (PIC)
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Piccolo Antikörper ist konjugiert mit HRP
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- Detects ~550 kDa. No cross-reactivity to Bassoon.
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Protein A Purified
- Immunogen
- Recombinant Full length Protein, BC001304.1
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- Applikationshinweise
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- WB (1:1000)
- IHC (1:400)
- optimal dilutions for assays should be determined by the user.
- Kommentare
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1 μg/ml of ABIN2482400 was sufficient for detection of Piccolo in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Conjugated antibodies should be stored at 4°C
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- Target
- Piccolo (PIC)
- Andere Bezeichnung
- Piccolo (PIC Produkte)
- Hintergrund
- Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).
- Gen-ID
- 27445
- NCBI Accession
- NP_055325
- UniProt
- Q9Y6V0
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