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Piccolo Antikörper (HRP)

PIC Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN2482400
  • Target Alle Piccolo (PIC) Produkte
    Piccolo (PIC)
    Reaktivität
    • 23
    • 16
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 19
    • 14
    • 1
    • 1
    Kaninchen
    Klonalität
    • 21
    • 14
    Polyklonal
    Konjugat
    • 15
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Piccolo Antikörper ist konjugiert mit HRP
    Applikation
    • 30
    • 16
    • 15
    • 12
    • 10
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    Detects ~550 kDa. No cross-reactivity to Bassoon.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein A Purified
    Immunogen
    Recombinant Full length Protein, BC001304.1
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:400)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2482400 was sufficient for detection of Piccolo in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    Piccolo (PIC)
    Andere Bezeichnung
    Piccolo (PIC Produkte)
    Hintergrund
    Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).
    Gen-ID
    27445
    NCBI Accession
    NP_055325
    UniProt
    Q9Y6V0
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