NALCN Antikörper (AA 1659-1738) (APC)
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- Target Alle NALCN Antikörper anzeigen
- NALCN (Sodium Leak Channel, Non-Selective (NALCN))
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Bindungsspezifität
- AA 1659-1738
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Reaktivität
- Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser NALCN Antikörper ist konjugiert mit APC
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Applikation
- Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Spezifität
- Detects ~200 kDa.
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Protein G Purified
- Immunogen
- Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
- Klon
- S187-7
- Isotyp
- IgG1
- Top Product
- Discover our top product NALCN Primärantikörper
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- Applikationshinweise
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- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- Kommentare
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1 μg/ml of ABIN2483028 was sufficient for detection of NALCN in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Conjugated antibodies should be stored at 4°C
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- Target
- NALCN (Sodium Leak Channel, Non-Selective (NALCN))
- Andere Bezeichnung
- NALCN (NALCN Produkte)
- Synonyme
- VGCNL1 antikoerper, zgc:113349 antikoerper, CanIon antikoerper, bA430M15.1 antikoerper, A530023G15Rik antikoerper, AI849508 antikoerper, Vgcnl1 antikoerper, sodium leak channel, non-selective antikoerper, NALCN antikoerper, nalcn antikoerper, Nalcn antikoerper
- Hintergrund
- NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.
- Gen-ID
- 266760
- NCBI Accession
- NP_705894
- UniProt
- Q6Q760
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