KCC2 Antikörper (AA 932-1043) (Biotin)
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- Target Alle KCC2 (SLC12A5) Antikörper anzeigen
- KCC2 (SLC12A5) (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))
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Bindungsspezifität
- AA 932-1043
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Reaktivität
- Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser KCC2 Antikörper ist konjugiert mit Biotin
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- Detects ~140 kDa.
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Protein G Purified
- Immunogen
- Fusion protein amino acids 932-1043 corresponding to rat KCC2
- Klon
- S1-12
- Isotyp
- IgG2a
- Top Product
- Discover our top product SLC12A5 Primärantikörper
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- Applikationshinweise
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- WB (1:1000)
- IHC (1:300)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- Kommentare
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1 μg/ml of ABIN2484117 was sufficient for detection of KCC2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Conjugated antibodies should be stored at 4°C
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- Target
- KCC2 (SLC12A5) (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))
- Andere Bezeichnung
- KCC2 (SLC12A5 Produkte)
- Synonyme
- Kcc2 antikoerper, KCC2 antikoerper, mKIAA1176 antikoerper, solute carrier family 12 member 5 antikoerper, solute carrier family 12, member 5 antikoerper, SLC12A5 antikoerper, Slc12a5 antikoerper
- Hintergrund
- KCC2 is a member of the cation-chloride cotransporter gene family (1). It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain (2, 3). KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord (4). Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior.
- Gen-ID
- 171373
- NCBI Accession
- NP_599190
- UniProt
- Q63633
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