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Bassoon Antikörper (AA 786-1041) (Atto 488)

BSN Reaktivität: Human IHC, WB Wirt: Kaninchen Polyclonal Atto 488
Produktnummer ABIN2484533
  • Target Alle Bassoon (BSN) Antikörper anzeigen
    Bassoon (BSN)
    Bindungsspezifität
    • 12
    • 2
    • 2
    • 1
    AA 786-1041
    Reaktivität
    • 24
    • 14
    • 14
    • 1
    • 1
    Human
    Wirt
    • 24
    • 3
    Kaninchen
    Klonalität
    • 24
    • 3
    Polyklonal
    Konjugat
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Bassoon Antikörper ist konjugiert mit Atto 488
    Applikation
    • 19
    • 17
    • 4
    • 4
    • 3
    • 2
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Spezifität
    Detects ~420 kDa. Multiple isoforms can be detected.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein A Purified
    Immunogen
    NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein
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  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:400)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2484533 was sufficient for detection of Bassoon in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    Bassoon (BSN)
    Andere Bezeichnung
    Bassoon (BSN Produkte)
    Synonyme
    Znf231 antikoerper, ZNF231 antikoerper, bassoon antikoerper, bassoon (presynaptic cytomatrix protein) antikoerper, bassoon presynaptic cytomatrix protein antikoerper, Bsn antikoerper, BSN antikoerper
    Hintergrund
    Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).
    Gen-ID
    8927
    NCBI Accession
    NP_003449
    UniProt
    Q9UPA5
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