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SHANK3 Antikörper (AA 840-857) (HRP)

SHANK3 Reaktivität: Ratte WB, IHC, IP, IF, ICC, AA Wirt: Maus Monoclonal S69 HRP
Produktnummer ABIN2485414
  • Target Alle SHANK3 Antikörper anzeigen
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    Bindungsspezifität
    • 15
    • 10
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 840-857
    Reaktivität
    • 43
    • 11
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 26
    • 21
    Maus
    Klonalität
    • 26
    • 21
    Monoklonal
    Konjugat
    • 14
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SHANK3 Antikörper ist konjugiert mit HRP
    Applikation
    • 31
    • 27
    • 22
    • 21
    • 16
    • 13
    • 13
    • 9
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    Spezifität
    Detects ~190 kDa. No cross-reactivity against Shank1 or Shank2.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Synthetic peptide amino acids 840-857 of rat Shank3
    Klon
    S69
    Isotyp
    IgG2b
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2485414 was sufficient for detection of Shank3 in 10 μg COS cell lysate transiently transfected with Shank3 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    Andere Bezeichnung
    SHANK3 (SHANK3 Produkte)
    Synonyme
    DEL22q13.3 antikoerper, PROSAP2 antikoerper, PSAP2 antikoerper, SCZD15 antikoerper, SPANK-2 antikoerper, Prosap2 antikoerper, AI841104 antikoerper, Shank3b antikoerper, SH3 and multiple ankyrin repeat domains 3 antikoerper, SH3 and multiple ankyrin repeat domains protein 3 antikoerper, SHANK3 antikoerper, shank3 antikoerper, Shank3 antikoerper
    Hintergrund
    Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling, specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (2). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (3).
    Gen-ID
    59312
    NCBI Accession
    NP_067708
    UniProt
    Q9JLU4
    Pathways
    Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
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