SLC12A3 Antikörper (AA 74-95) (Biotin)
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- Target Alle SLC12A3 Antikörper anzeigen
- SLC12A3 (Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3))
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Bindungsspezifität
- AA 74-95
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SLC12A3 Antikörper ist konjugiert mit Biotin
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoelectron Microscopy (IEM), Immunofluorescence (IF)
- Spezifität
- Detects ~160 kDa.
- Kreuzreaktivität
- Hund, Human, Maus, Ratte
- Aufreinigung
- Affinity Purified
- Immunogen
- Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal
- Top Product
- Discover our top product SLC12A3 Primärantikörper
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- Applikationshinweise
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- WB (1:1000)
- IHC (1:200)
- optimal dilutions for assays should be determined by the user.
- Kommentare
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1 μg/ml of ABIN2486292 was sufficient for detection of NCC3 in 10 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Conjugated antibodies should be stored at 4°C
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- Target
- SLC12A3 (Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3))
- Andere Bezeichnung
- NCC (SLC12A3 Produkte)
- Synonyme
- SLC12A3 antikoerper, slc12a3 antikoerper, DKFZp469N2315 antikoerper, NCC antikoerper, NCCT antikoerper, TSC antikoerper, AI035291 antikoerper, solute carrier family 12 member 3 antikoerper, solute carrier family 12 (sodium/chloride transporter), member 3 antikoerper, solute carrier family 12, member 3 antikoerper, SLC12A3 antikoerper, slc12a3.2 antikoerper, Slc12a3 antikoerper
- Hintergrund
- NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis (1). Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC (2). Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension (1). Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat (3).
- Gen-ID
- 54300, 6559
- NCBI Accession
- NP_062218, NP_000330
- UniProt
- P55018, P55017
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