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AQP2 Antikörper (C-Term) (APC)

AQP2 Reaktivität: Ratte WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal APC
Produktnummer ABIN2486376
  • Target Alle AQP2 Antikörper anzeigen
    AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))
    Bindungsspezifität
    • 21
    • 20
    • 17
    • 16
    • 15
    • 15
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 108
    • 96
    • 80
    • 15
    • 15
    • 10
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Ratte
    Wirt
    • 130
    • 2
    Kaninchen
    Klonalität
    • 131
    • 2
    Polyklonal
    Konjugat
    • 47
    • 10
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AQP2 Antikörper ist konjugiert mit APC
    Applikation
    • 115
    • 41
    • 41
    • 40
    • 28
    • 19
    • 19
    • 18
    • 16
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~28.8 kDa. May detect larger glycosylated bands ~35-50 kDa.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein A Purified
    Immunogen
    Produced against the C-terminal peptide (Sequence N-CLKGLEPDTDWEEREVRRRQ) of rat aquaporin 2
    Top Product
    Discover our top product AQP2 Primärantikörper
  • Applikationshinweise
    • WB (1:2000)
    • IHC (1:200)
    • ICC/IF (1:400)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    0.5 μg/ml of ABIN2486376 was sufficient for detection of aquaporin 2 in 10 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    AQP2 (Aquaporin 2 (Collecting Duct) (AQP2))
    Andere Bezeichnung
    Aquaporin 2 (AQP2 Produkte)
    Synonyme
    AQP-CD antikoerper, WCH-CD antikoerper, cph antikoerper, jpk antikoerper, AQP-2 antikoerper, aquaporin-2 antikoerper, aquaporin 2 antikoerper, aquaporin 2 (collecting duct) antikoerper, Aqp2 antikoerper, AQP2 antikoerper
    Hintergrund
    Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 2 is the vasopressin-regulated water channel of the apical membrane of collecting duct cells. It is located in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. When it is needed vasopressin binds to the cell surface vasopressin receptor, activating a signaling pathway that cause AQP2 containing vesicles to fuse with the plasma membrane so the AQP2 can be used by the cell (3). Defects in AQP2 area cause of an autosomal dominant form of nephrogenic diabetes insipidus (NDI) (4).
    Gen-ID
    25386
    NCBI Accession
    NP_037041
    UniProt
    P34080
    Pathways
    Response to Water Deprivation
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