Abeta 1-42 Antikörper

Produktnummer ABIN249343

Produktdetails anti-Abeta 1-42 Antikörper

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Abeta 1-42 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Dot Blot (DB), Immunolocalization (IL)

Kreuzreaktivität (Details): Not reactive in: no confirmed exceptions from predicted reactivity known in the moment

Homologie: bovine, chicken, dog, porcine, rabbit

Produktmerkmale: Expected / apparent Molecular Weight of the Antigene: 4.5 kDa

Aufreinigung: serum

Immunogen: synthetic peptide chosen from human Abeta (1-42) protein. Amino acid sequence: D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V-I-A

Anwendungsinformationen

Applikationshinweise: 1:1000 (DB), 1:3000 (ELISA), 1-2 μg/mL (IL)

Kommentare:

the antibody can detect Abeta (1-42), Abeta (1-28) Abeta (1-20) and Abeta (1-17). This product exhibits a low reactivity to monomeric Abeta (1-42) as determined by SDS-PAGE and Western blotting.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: For reconstitution add 100 μL of sterile water.

Handhabung: Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
Once reconstituted make aliquots to avoid repreated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: store lyophilized/reconstituted at -20°C, once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Referenzen für anti-Abeta 1-42 Antikörper (ABIN249343)

Lindhagen-Persson, Brännström, Vestling, Steinitz, Olofsson: "Amyloid-? oligomer specificity mediated by the IgM isotype--implications for a specific protective mechanism exerted by endogenous auto-antibodies." in: PLoS ONE, Vol. 5, Issue 11, pp. e13928, (2010) (PubMed).

Details zu Abeta 1-42

Target: Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))

Andere Bezeichnung: Amyloid-beta 42 protein (Abeta (1-42)) (Abeta 1-42 Produkte)

Synonyme: amyloid beta precursor protein antikoerper, App antikoerper, APP antikoerper

Hintergrund: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of the amyloid precursor protein P05067

Molekulargewicht: 4.5 kDa