CBX4 Antikörper (AA 401-500)

Produktnummer ABIN2559520

Produktdetails anti-CBX4 Antikörper

Target: CBX4 (Chromobox Homolog 4 (CBX4))

Bindungsspezifität: AA 401-500

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBX4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CBX4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CBX4 Antikörper (ABIN2559520)

Han, Wang, Li, Dong, Zhang, Yan: "HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells." in: Graefe's archive for clinical and experimental ophthalmology, Vol. 253, Issue 8, pp. 1279-90, (2015) (PubMed).

Details zu CBX4

Target: CBX4 (Chromobox Homolog 4 (CBX4))

Andere Bezeichnung: CBX4 (CBX4 Produkte)

Synonyme: MPc2 antikoerper, PC2 antikoerper, NBP16 antikoerper, XPolycomb antikoerper, cbx4-a antikoerper, im:6911625 antikoerper, zgc:158588 antikoerper, chromobox 4 antikoerper, chromobox 4 S homeolog antikoerper, chromobox homolog 4 antikoerper, chromobox homolog 4 (Pc class homolog, Drosophila) antikoerper, CBX4 antikoerper, Cbx4 antikoerper, cbx4.S antikoerper, cbx4 antikoerper

Hintergrund:

Synonyms: PC2, NBP16, E3 SUMO-protein ligase CBX4, Chromobox protein homolog 4, Polycomb 2 homolog, hPc2, CBX4

Background: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Gen-ID: 8535

UniProt: O00257