×
Aktivieren Sie Javascript in Ihrem Browser, um unsere Webseite optimal zu nutzen.
eIF4EBP1 Antikörper (pThr70)
EIF4EBP1
Reaktivität: Human
IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2567033
Produktdetails anti-eIF4EBP1 Antikörper
(ausblenden)
Target
Alle eIF4EBP1 (EIF4EBP1) Antikörper anzeigen
eIF4EBP1 (EIF4EBP1)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
Bindungsspezifität
Alle Epitope für eIF4EBP1 Antikörper
pThr70
Reaktivität
Alle Reaktivitäten für eIF4EBP1 Antikörper
Human
Wirt
Alle Wirte für eIF4EBP1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für eIF4EBP1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für eIF4EBP1 Antikörper
Dieser eIF4EBP1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für eIF4EBP1 Antikörper
Immunohistochemistry (IHC)
Spezifität
The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70.
Aufreinigung
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
4E-BP1 (phospho Thr70) antibody was raised against a peptide sequence around phosphorylation site of threonine70 (T-K-T (p)-P-P) derived from Human 4E-BP1.
Isotyp
IgG
Top Product
Discover our top product EIF4EBP1 Primärantikörper
Alternativen
(anzeigen)
Anwendungsinformationen
(ausblenden)
Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
(ausblenden)
Format
Liquid
Konzentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Store antibody at -20°C for up to one year.
Details zu eIF4EBP1
(ausblenden)
Target
eIF4EBP1 (EIF4EBP1)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
Andere Bezeichnung
4E-BP1 (EIF4EBP1 Produkte )
Synonyme
4E-BP1 antikoerper, 4EBP1 antikoerper, BP-1 antikoerper, PHAS-I antikoerper, 4e-bp1 antikoerper, AA959816 antikoerper, 153432_at antikoerper, 43-BP antikoerper, 4E-BP antikoerper, 4EBP antikoerper, 4e-bp antikoerper, 4eBP antikoerper, 4ebp antikoerper, BcDNA.HL08053 antikoerper, BcDNA:HL08053 antikoerper, CG8846 antikoerper, CT8705 antikoerper, Dm 4E-BP antikoerper, Dmel\\CG8846 antikoerper, Phas1 antikoerper, Thor/EIF4EBP antikoerper, anon-WO0172774.158 antikoerper, d4E-BP antikoerper, d4E-BP1 antikoerper, d4EBP antikoerper, d4e-bp antikoerper, d4eBP antikoerper, dthor antikoerper, eIF4E-BP antikoerper, l(2)06270 antikoerper, l(2)k07736 antikoerper, l(2)k13517 antikoerper, pp20 antikoerper, thor antikoerper, EIF4EBP1 antikoerper, fc04h09 antikoerper, wu:fc04h09 antikoerper, zgc:64137 antikoerper, eukaryotic translation initiation factor 4E binding protein 1 antikoerper, CG8846 gene product from transcript CG8846-RA antikoerper, EIF4EBP1 antikoerper, Eif4ebp1 antikoerper, Thor antikoerper, eif4ebp1 antikoerper
Hintergrund
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Molekulargewicht
12 kDa
Gen-ID
1978
NCBI Accession
NP_004086
UniProt
Q13541
Pathways
MAPK Signalweg , PI3K-Akt Signalweg , RTK Signalweg , AMPK Signaling , Regulation of Cell Size , BCR Signaling
Zuletzt angesehen
(ausblenden)