The antibody detects endogenous level of FANCD2 only when phosphorylated at serine 222.
Aufreinigung
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
FANCD2 (phospho Ser222) antibody was raised against a peptide sequence around phosphorylation site of serine 222 (G-D-S (p)-Q-H) derived from Human FANCD2.
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.