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AHNAK Antikörper (N-Term)

AHNAK Reaktivität: Human, Maus WB, IP, IHC (fro), IF Wirt: Maus Monoclonal EM-09 unconjugated
Produktnummer ABIN263928
  • Target Alle AHNAK Antikörper anzeigen
    AHNAK (AHNAK Nucleoprotein (AHNAK))
    Bindungsspezifität
    • 15
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 48
    • 10
    • 1
    Human, Maus
    Wirt
    • 33
    • 13
    • 2
    Maus
    Klonalität
    • 38
    • 10
    Monoklonal
    Konjugat
    • 23
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AHNAK Antikörper ist unkonjugiert
    Applikation
    • 16
    • 16
    • 13
    • 13
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
    Spezifität
    The antibody reacts with AHNAK1, a 700 kDa multi-functional adaptor protein expressed mainly in epithelial cell, various types of muscle cells and immune cells.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse.
    Produktmerkmale
    Synonyms: Desmoyokin, Neuroblast differentiation-associated protein AHNAK
    Aufreinigung
    Protein A Affinity Chromatography
    Immunogen
    Bacterially expressed fragment of N-terminal domain of human AHNAK1
    Klon
    EM-09
    Isotyp
    IgG1
    Top Product
    Discover our top product AHNAK Primärantikörper
  • Applikationshinweise
    Immunohistochemistry on frozen sections. Western blot (Positive control: HeLa human cervix carcinoma cell line). Immunocytochemistry (Permeabilization is required, positive control: HeLa human cervixcarcinoma cell line). Immunoprecipitation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS, pH ~7.4, 15 mM Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 to -80 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Haltbarkeit
    12 months
  • Target
    AHNAK (AHNAK Nucleoprotein (AHNAK))
    Abstract
    AHNAK Produkte
    Synonyme
    AHNAKRS antikoerper, 1110004P15Rik antikoerper, 2310047C17Rik antikoerper, AA589382 antikoerper, AV091586 antikoerper, DY6 antikoerper, AHNAK 1 antikoerper, RGD1308572 antikoerper, UV118 antikoerper, AHNAK antikoerper, wu:fb05a01 antikoerper, wu:fu74f12 antikoerper, LOC733715 antikoerper, AHNAK nucleoprotein antikoerper, AHNAK nucleoprotein (desmoyokin) antikoerper, AHNAK nucleoprotein pseudogene antikoerper, AHNAK antikoerper, Ahnak antikoerper, ahnak antikoerper, LOC748622 antikoerper
    Hintergrund
    AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear, it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.Synonyms: Desmoyokin, Neuroblast differentiation-associated protein AHNAK
    Gen-ID
    79026
    UniProt
    Q09666
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