Valproic Acid Antikörper

Produktnummer ABIN5610817

Produktdetails anti-Valproic Acid Antikörper

Target: Valproic Acid

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Valproic Acid Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA)

Aufreinigung: Protein G chromatography

Immunogen: Valproic acid conjugated to KLH

Klon: 801

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: May be used in immunoassays to detect and quantitate valproic acid.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.2mg/mL (OD280nm)

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu Valproic Acid

Target: Valproic Acid

Abstract: Valproic Acid Produkte

Substanzklasse: Chemical

Hintergrund: Valproic acid, valproate sodium and divalproex belong to the group of medicines called anticonvulsants, used to control certain types of seizures in the treatment of epilepsy. Also, valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic centre of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed haematopoietic progenitor cells and leukaemic blasts from acute myeloid leukaemia patients. Moreover, tumour growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.