Caspase 6 Antikörper

Produktnummer ABIN264405

Produktdetails anti-Caspase 6 Antikörper

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Caspase 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Detects proenzyme form of human Caspase-6 by Western blot.

Produktmerkmale: Synonyms: CASP-6, CASP6, MCH2, MCH-2, Apoptotic protease Mch-2

Aufreinigung: Purified

Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-6 protein and mouse myeloma cells. Genename: CASP6

Klon: MCH2 14 1-190

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot. Positive Control: MCF-7 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.08 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch

Haltbarkeit: 12 months

Details zu Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Andere Bezeichnung: Caspase-6 (CASP6 Produkte)

Hintergrund: Caspase-6 (Cysteine-Requiring Aspartate Proteases) is part of a family of intracellular cysteine proteases that cleave their substrates after aspartic acid residues. These proteases play an integral role in inducing apoptosis in cells. Procaspase-6 (Mch2), a member of the ICE/ced-3 subfamily, is an inactive proenzyme that is activated to form caspase-6 by proteolytic cleavage at certain aspartic acid residues. During cleavage, the N-terminal is removed and the proenzyme is converted into a large (p18) and small (p11) subunits. Caspase-6 has two isoforms produced by alternative splicing. Over-expression of the isoform of caspase-6 without its prodomain can induce apoptosis. The isoform does not seem to display proteolytic activity. Together with caspases-3 and -7, the isoform of caspase-6 is classified as an effector/execution caspase. Caspase-3, caspase-8 and caspase-10 can cleave procaspase-6. Active caspase-6 cleaves several other proteins such as lamins, NuMa and Keratin 18. A possible cleavage of caspases-8 and -10 in cytochrome-C dependent apoptosis was reported recently.Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2

Gen-ID: 839

UniProt: P55212

Pathways: Apoptose, Caspase Kaskade in der Apoptose