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p53 Antikörper (AA 371-380)

Name: p53 Antikörper (AA 371-380)
SKU: ABIN264449
Price: 1082.31 EUR
Availability: InStock

TP53 Reaktivität: Human, Maus, Ratte, Affe WB, IP, IHC (fro), EIA Wirt: Maus Monoclonal HR231 unconjugated

Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (AA 371-380) antibody (ABIN264449) (p53 Antikörper (AA 371-380))

2 Abbildungen

Produktnummer ABIN264449

Datenblatt (PDF)

Target Alle p53 (TP53) Antikörper anzeigen

p53 (TP53) (Tumor Protein P53 (TP53))
Bindungsspezifität
43

40

37

30

29

29

26

26

24

22

20

20

19

19

18

18

16

15

13

9

8

8

7

7

7

6

6

6

6

6

6

6

5

5

4

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3
AA 371-380
Reaktivität
834

254

210

106

50

34

33

19

10

9

7

6

6

3

3

3

3

2

2

2

2

1

1

1
Human, Maus, Ratte, Affe
Wirt
623

228

6

2

1
Maus
Passende Sekundärantikörper
Klonalität
559

300

1
Monoklonal
Konjugat
484

38

32

19

19

13

13

13

13

13

13

13

13

13

12

12

11

11

11

11

11

11

11

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
Dieser p53 Antikörper ist unkonjugiert
Applikation
667

298

250

202

200

149

127

124

119

67

59

35

18

16

13

11

9

9

8

6

4

3

3

3

3

2

2

2

1

1

1

1

1
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Spezifität

This antibody reacts to p53.

Kreuzreaktivität (Details)

Species reactivity (tested):Human, Monkey, Mouse and Rat.

Produktmerkmale

Synonyms: Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13

Aufreinigung

Affinity chromatography on Protein A/G

Immunogen

Hybridoma produced by the fusion of splenocytes from immunized with full length humanp53 protein and mouse myeloma cells.

Klon

HR231

Isotyp

IgG2b

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Applikationshinweise

Western Blot (1-5 μg/mL). ELISA. Immunoprecipitation. Immunohistochemistry. Positive Control: Breast or colon carcinoma cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1,0 mg/mL

Buffer

PBS, 0.08 % Sodium Azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Haltbarkeit

12 months
Target

p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung

p53 (TP53) (TP53 Produkte)

Hintergrund

P53 is a 53 kDa transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53

Gen-ID

7157

UniProt

P04637

Pathways

p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt