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VSX2 Antikörper (C-Term)

VSX2 Reaktivität: Maus, Ratte WB, IHC (fro) Wirt: Schaf Polyclonal unconjugated
Produktnummer ABIN265010
  • Target Alle VSX2 Antikörper anzeigen
    VSX2 (Visual System Homeobox 2 (VSX2))
    Bindungsspezifität
    • 10
    • 9
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 264-361, C-Term
    Reaktivität
    • 36
    • 16
    • 6
    • 1
    Maus, Ratte
    Wirt
    • 39
    • 4
    • 1
    Schaf
    Klonalität
    • 43
    • 1
    Polyklonal
    Konjugat
    • 21
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser VSX2 Antikörper ist unkonjugiert
    Applikation
    • 37
    • 16
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This antibody recognizes chx 10 (C-Term). Other species not tested.
    Aufreinigung
    Purified
    Immunogen
    Antibody raised against a recombinant protein corresponding to amino acids 264 to 361 derived from the C terminal of the human Chx10 protein conjugated to GST.
    Isotyp
    IgG
    Top Product
    Discover our top product VSX2 Primärantikörper
  • Applikationshinweise
    Western Blot: 0.5-1.0 mg/mL. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Immunohistochemistry on Frozen Sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS containing 0.08 % Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C. Can be shipped at ambient temperature.
  • Francius, Harris, Rucchin, Hendricks, Stam, Barber, Kurek, Grosveld, Pierani, Goulding, Clotman: "Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord." in: PLoS ONE, Vol. 8, Issue 8, pp. e70325, (2013) (PubMed).

    Nittner, Lambertz, Clermont, Mestdagh, Köhler, Nielsen, Jochemsen, Speleman, Vandesompele, Dyer, Schramm, Schulte, Marine: "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." in: Nature cell biology, Vol. 14, Issue 9, pp. 958-65, (2012) (PubMed).

    Qiu, Jiang, Xiang: "A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 13, pp. 3392-403, (2008) (PubMed).

    Elshatory, Everhart, Deng, Xie, Barlow, Gan: "Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 46, pp. 12707-20, (2007) (PubMed).

    Osakada, Ooto, Akagi, Mandai, Akaike, Takahashi: "Wnt signaling promotes regeneration in the retina of adult mammals." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 15, pp. 4210-9, (2007) (PubMed).

  • Target
    VSX2 (Visual System Homeobox 2 (VSX2))
    Andere Bezeichnung
    VSX2 / CHX10 (VSX2 Produkte)
    Synonyme
    CHX10 antikoerper, HOX10 antikoerper, MCOP2 antikoerper, MCOPCB3 antikoerper, RET1 antikoerper, Chx10 antikoerper, Hox-10 antikoerper, Hox10 antikoerper, or antikoerper, VSX2 antikoerper, Vsx-2 antikoerper, alx antikoerper, chx10 antikoerper, c-ret antikoerper, cret antikoerper, etID315074.13 antikoerper, ret1 antikoerper, wu:fd13h01 antikoerper, visual system homeobox 2 antikoerper, ret proto-oncogene receptor tyrosine kinase antikoerper, Vsx2 transcription factor antikoerper, VSX2 antikoerper, Vsx2 antikoerper, vsx2 antikoerper, ret antikoerper
    Hintergrund
    Chx10 is a 46 kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.Synonyms: Ceh-10 homeodomain-containing homolog, HOX10, Homeobox protein CHX10, Visual system homeobox 2
    Molekulargewicht
    46 kDa
    Gen-ID
    12677
    NCBI Accession
    NP_031727
    UniProt
    Q61412
    Pathways
    Dopaminergic Neurogenesis
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