VSX2 Antikörper (N-Term)

Produktnummer ABIN265011

Produktdetails anti-VSX2 Antikörper

Target: VSX2 (Visual System Homeobox 2 (VSX2))

Bindungsspezifität: AA 1-131, N-Term

Reaktivität: Maus, Ratte

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser VSX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody recognizes chx 10 (N-Term).

Aufreinigung: Purified

Immunogen: Antibody raised against a recombinant protein corresponding to amino acids 1 to 131 derived from the N terminal of the human Chx10 protein conjugated to GST.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5-1.0 mg/mL. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Immunohistochemistry on Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.08 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C. Can be shipped at ambient temperature.

Referenzen für anti-VSX2 Antikörper (ABIN265011)

Bai, Kiyama, Li, Wang: "Birth of cone bipolar cells, but not rod bipolar cells, is associated with existing RGCs." in: PLoS ONE, Vol. 9, Issue 1, pp. e83686, (2014) (PubMed).

Haynes, Luz-Madrigal, Reis, Echeverri Ruiz, Grajales-Esquivel, Tzekou, Tsonis, Lambris, Del Rio-Tsonis: "Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration." in: Nature communications, Vol. 4, pp. 2312, (2013) (PubMed).

Tiwari, Hudson, Gattone, Miller, Chernoff, Belecky-Adams: "Meckelin 3 is necessary for photoreceptor outer segment development in rat Meckel syndrome." in: PLoS ONE, Vol. 8, Issue 3, pp. e59306, (2013) (PubMed).

Luo, Jin, Xie, Qiu, Li, Zou, Cai, Hozumi, Shima, Xiang: "Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 9, pp. E553-62, (2012) (PubMed).

Sherry, Kanan, Hamilton, Hoffhines, Arbogast, Fliesler, Naash, Moore, Al-Ubaidi: "Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2." in: PLoS ONE, Vol. 7, Issue 6, pp. e39702, (2012) (PubMed).

Wakabayashi, Kosaka, Mori, Yamada: "Prolonged expression of Puma in cholinergic amacrine cells during the development of rat retina." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 60, Issue 10, pp. 777-88, (2012) (PubMed).

Nittner, Lambertz, Clermont, Mestdagh, Köhler, Nielsen, Jochemsen, Speleman, Vandesompele, Dyer, Schramm, Schulte, Marine: "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." in: Nature cell biology, Vol. 14, Issue 9, pp. 958-65, (2012) (PubMed).

Elshatory, Everhart, Deng, Xie, Barlow, Gan: "Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 46, pp. 12707-20, (2007) (PubMed).

Osakada, Ooto, Akagi, Mandai, Akaike, Takahashi: "Wnt signaling promotes regeneration in the retina of adult mammals." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 15, pp. 4210-9, (2007) (PubMed).

Yun, Sun, Wang, Rusovici, Castleberry, Hall, Shim: "LPA2 receptor mediates mitogenic signals in human colon cancer cells." in: American journal of physiology. Cell physiology, Vol. 289, Issue 1, pp. C2-11, (2005) (PubMed).

Dorsam, Graeler, Seroogy, Kong, Voice, Goetzl: "Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 7, pp. 3500-7, (2003) (PubMed).

Details zu VSX2

Target: VSX2 (Visual System Homeobox 2 (VSX2))

Andere Bezeichnung: VSX2 / CHX10 (VSX2 Produkte)

Synonyme: CHX10 antikoerper, HOX10 antikoerper, MCOP2 antikoerper, MCOPCB3 antikoerper, RET1 antikoerper, Chx10 antikoerper, Hox-10 antikoerper, Hox10 antikoerper, or antikoerper, VSX2 antikoerper, Vsx-2 antikoerper, alx antikoerper, chx10 antikoerper, c-ret antikoerper, cret antikoerper, etID315074.13 antikoerper, ret1 antikoerper, wu:fd13h01 antikoerper, visual system homeobox 2 antikoerper, ret proto-oncogene receptor tyrosine kinase antikoerper, Vsx2 transcription factor antikoerper, VSX2 antikoerper, Vsx2 antikoerper, vsx2 antikoerper, ret antikoerper

Hintergrund: Chx10 is a 46 kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.Synonyms: Ceh-10 homeodomain-containing homolog, HOX10, Homeobox protein CHX10, Visual system homeobox 2

Molekulargewicht: 46 kDa

Gen-ID: 12677

NCBI Accession: NP_031727

UniProt: Q61412

Pathways: Dopaminergic Neurogenesis