S1PR4 Antikörper (C-Term)

Produktnummer ABIN265012

Produktdetails anti-S1PR4 Antikörper

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser S1PR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody recognizes Human EDG-6 / S1P4 / S1PR4. Other species not tested.

Aufreinigung: Purified

Immunogen: Synthetic peptide derived from the C-terminal of the EDG-6 receptor.

Anwendungsinformationen

Applikationshinweise: Western Blot: Detects EDG-6 receptors at concentration of 5-10 μg/mL by Western blotusing a human EDG-6 receptor transfected cell line. Detects an approximately 45 kDa bandin Cos cells transfected with full length human EDG-6. Due to low expression of EDGreceptors, we recommend use of Pierce Femto Signal substrate for western blotdevelopment.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 0.08 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu S1PR4

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Andere Bezeichnung: S1PR4 / EDG6 (S1PR4 Produkte)

Hintergrund: EDG-6 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-6 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-6 is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG-6 receptor is the sphingosine 1-phosphate receptor-4 (S1P-4).Synonyms: EDG-6, Endothelial differentiation G-protein coupled receptor 6, S1P receptor Edg-6, Sphingosine 1-phosphate receptor 4, Sphingosine 1-phosphate receptor Edg-6

Gen-ID: 8698

NCBI Accession: NP_003766

UniProt: O95977