TYROBP
Reaktivität: Human
ELISA, IHC (p)
Wirt: Ziege
Polyclonal
unconjugated
Applikationshinweise
Western Blot. Immunoprecipitation: Use 2-4 μg/mL of protein lysate. Positive Control: NKp44 positive cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Buffer
PBS, 0.08 % Sodium Azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
Target
TYROBP
(TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).Synonyms: DNAX-activation protein 12, KARAP, Killer-activating receptor-associated protein, TYRO protein tyrosine kinase-binding protein