IKZF2 Antikörper (Alexa Fluor 488)

Produktnummer ABIN2657510

Produktdetails anti-IKZF2 Antikörper (Alexa Fluor 488)

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Reaktivität: Human, Maus

Wirt: Armenischer Hamster

Klonalität: Monoklonal

Konjugat: Dieser IKZF2 Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.

Klon: 22F6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C

Details zu IKZF2

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Andere Bezeichnung: Helios (IKZF2 Produkte)

Synonyme: ANF1A2 antikoerper, HELIOS antikoerper, ZNF1A2 antikoerper, ZNFN1A2 antikoerper, helios antikoerper, znf1a2 antikoerper, znfn1a1 antikoerper, znfn1a2 antikoerper, IKZF2 antikoerper, MGC159581 antikoerper, DKFZp469N0319 antikoerper, A730095J18Rik antikoerper, Helios antikoerper, Zfpn1a2 antikoerper, Znfn1a2 antikoerper, ikzf2 antikoerper, znfn1a1-a antikoerper, IKAROS family zinc finger 2 antikoerper, si:zfos-1425h8.1 antikoerper, IKAROS family zinc finger 2 (Helios) antikoerper, IKAROS family zinc finger 2 L homeolog antikoerper, IKZF2 antikoerper, ikzf2 antikoerper, Ikzf2 antikoerper, si:zfos-1425h8.1 antikoerper, ikzf2.L antikoerper

Hintergrund: Helios is a member of the Ikaros family of zinc finger transcription factors. It contains a C-terminal region composed of 2 zinc-finger domains that mediate dimerization between the family members. Helios was originally cloned from a mouse thymoma line. It is mainly expressed in peripheral T cells and thymocytes. It is found at high levels in a subpopulation of regulatory T cells. Helios plays an important role in T cell development and homeostasis. Overexpression of Helios profoundly alters αβ T cell differentiation and activation. It has been determined that silencing of Helios in B cells is critical for maintaining normal B cell function. Helios is also involved in tumor immunity.