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SIGLEC8 Antikörper (APC)

SIGLEC8 Reaktivität: Human FACS, ICFC Wirt: Maus Monoclonal 7C9 APC
Produktnummer ABIN2658389
  • Target Alle SIGLEC8 Antikörper anzeigen
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Reaktivität
    • 42
    • 6
    • 2
    Human
    Wirt
    • 32
    • 9
    • 1
    Maus
    Klonalität
    • 34
    • 8
    Monoklonal
    Konjugat
    • 23
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIGLEC8 Antikörper ist konjugiert mit APC
    Applikation
    • 32
    • 20
    • 19
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
    Aufreinigung
    The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    Klon
    7C9
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product SIGLEC8 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Protect from prolonged exposure to light. Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Andere Bezeichnung
    Siglec-8 (SIGLEC8 Produkte)
    Synonyme
    SAF2 antikoerper, SIGLEC-8 antikoerper, SIGLEC8L antikoerper, SIGLEC8 antikoerper, sialic acid binding Ig like lectin 8 antikoerper, sialic acid-binding Ig-like lectin 8 antikoerper, SIGLEC8 antikoerper, LOC506364 antikoerper
    Hintergrund
    Siglec-8 is a lectin specific for 6'-sulfo-sLex and a member of the Ig-superfamily. It is expressed almost exclusively in eosinophils, however, basophils and mast cells can express it to a lower degree. Siglec-8 is a 54 kD transmembranal protein, the extracellular domain has one V-set Ig-like domain and two C2-set domains. The cytoplasmic domain has two immunoreceptor tyrosine-based inhibitor motifs (ITIM) that recruit SH2-family phosphatases after tyrosine phosphorylation. There are reports that siglec-8 inhibits the release of histamine and prostaglandin D2 mediated by the IgEFcR. This molelcule is also involved in the induction of apoptosis.
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