SIGLEC8 Antikörper (APC)

Produktnummer ABIN2658389

Produktdetails anti-SIGLEC8 Antikörper (APC)

Target: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIGLEC8 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Klon: 7C9

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu SIGLEC8

Target: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Andere Bezeichnung: Siglec-8 (SIGLEC8 Produkte)

Synonyme: SAF2 antikoerper, SIGLEC-8 antikoerper, SIGLEC8L antikoerper, SIGLEC8 antikoerper, sialic acid binding Ig like lectin 8 antikoerper, sialic acid-binding Ig-like lectin 8 antikoerper, SIGLEC8 antikoerper, LOC506364 antikoerper

Hintergrund: Siglec-8 is a lectin specific for 6'-sulfo-sLex and a member of the Ig-superfamily. It is expressed almost exclusively in eosinophils, however, basophils and mast cells can express it to a lower degree. Siglec-8 is a 54 kD transmembranal protein, the extracellular domain has one V-set Ig-like domain and two C2-set domains. The cytoplasmic domain has two immunoreceptor tyrosine-based inhibitor motifs (ITIM) that recruit SH2-family phosphatases after tyrosine phosphorylation. There are reports that siglec-8 inhibits the release of histamine and prostaglandin D2 mediated by the IgEFcR. This molelcule is also involved in the induction of apoptosis.