ERBB3 Antikörper (APC)

Produktnummer ABIN2658752

Produktdetails anti-ERBB3 Antikörper (APC)

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ERBB3 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Klon: 1B4C3

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Andere Bezeichnung: ErbB3/HER-3 (ERBB3 Produkte)

Synonyme: ErbB-3 antikoerper, HER3 antikoerper, LCCS2 antikoerper, MDA-BF-1 antikoerper, c-erbB-3 antikoerper, c-erbB3 antikoerper, erbB3-S antikoerper, p180-ErbB3 antikoerper, p45-sErbB3 antikoerper, p85-sErbB3 antikoerper, ERBB3 antikoerper, C76256 antikoerper, Erbb-3 antikoerper, Erbb3r antikoerper, Her3 antikoerper, nuc-ErbB3 antikoerper, erb-b2 receptor tyrosine kinase 3 antikoerper, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antikoerper, ERBB3 antikoerper, Erbb3 antikoerper

Hintergrund: ErbB3/HER3 is a receptor tyrosine kinase and a member of the epidermal growth factor receptor family. erbB3/HER3 binds the heregulin ligands and contains 4 furin-like repeats, 2 cheY receiver domains, and a tyrosine kinase domain with a predicted molecular weight approximately 148 kD. Signaling through the erbB3/HER3 receptor induces proliferation and differentiation in some cell types, the receptor is widely expressed in many tissues including kidney, lung, brain, placenta, skin and stomach. erbB3/HER3 forms constitutively active heterodimers with erbB2/HER2 in a subset of human mammary tumors, expression of erbB3/HER3 reported be linked to favorable outcome in bladder and ovarian cancer. erbB3/HER3 has been shown to interact with a number of proteins including EGF receptor, erbB2/HER2, erbB4, Grb2, Grb7, SOS1, cdk5, SHC, FAK, PTK6, and others. The erbB3/HER3 receptor is extensively phosphorylated at residues T873 and S1123 (by cdk5), Y1199, Y1262, Y1289, and Y1328. The 1B4C3 antibody has been shown to be useful for flow cytometric detection of human erbB3/HER3.

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung