CTLA4
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
Reaktivität
Maus
Wirt
Hamster
Klonalität
Monoklonal
Konjugat
Dieser CTLA4 Antikörper ist konjugiert mit PE/Dazzle™ 594
Applikation
Flow Cytometry (FACS)
Aufreinigung
The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions. The solution is free of unconjugated PE/Dazzle™ 594 and unconjugated antibody.
CD152, also known as CTLA-4 or Ly-56, is a 33 kD member of the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.