Dieser Sca-1/Ly-6A/E Antikörper ist konjugiert mit Biotin
Applikation
Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)
Aufreinigung
The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Ly-6A.2 antikoerper, Ly-6A/E antikoerper, Ly-6E.1 antikoerper, Sca-1 antikoerper, Sca1 antikoerper, TAP antikoerper, lymphocyte antigen 6 complex, locus A antikoerper, Ly6a antikoerper
Hintergrund
Ly-6A/E, also known as Sca-1, is an 18 kD member of the Ly-6 multigene family. Ly6A/E is a glycosylphosphatidylinositol (GPI)-linked protein expressed on hematopoietic stem cells. In mice expressing the Ly-6.2 haplotype (e.g., AKR, C57BL, C57BR, DBA/2, SJL, SWR, and 129), Ly-6A/E is also expressed on peripheral B lymphocytes and thymic and peripheral T lymphocytes. Strains expressing the Ly-6.1 haplotype (e.g., BALB/c, CBA, C3H/He, DBA/1, and NZB) have low Ly-6A/E expression on resting peripheral lymphocytes. The expression of Ly-6A/E on lymphocytes is upregulated upon activation from both Ly6.1 and Ly6.2 haplotype mice. Ly-6A/E is thought to be involved in the regulation of both T and B cell responses.