Dieser SLAMF1 Antikörper ist konjugiert mit Pacific Blue
Applikation
Flow Cytometry (FACS), Blocking Reagent (BR)
Aufreinigung
The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions. The solution is free of unconjugated Pacific Blue™.
CD150 antikoerper, SLAM antikoerper, SLAMF1 antikoerper, 4933415F16 antikoerper, AA177906 antikoerper, CDw150 antikoerper, ESTM51 antikoerper, IPO-3 antikoerper, Slam antikoerper, RGD1560634 antikoerper, signaling lymphocytic activation molecule family member 1 antikoerper, SLAMF1 antikoerper, Slamf1 antikoerper
Hintergrund
CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.