Dieser KIR2DL4/CD158d Antikörper ist konjugiert mit PE
Applikation
Flow Cytometry (FACS), Immunoprecipitation (IP)
Aufreinigung
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
G9P antikoerper, CD158D antikoerper, KIR103 antikoerper, KIR103AS antikoerper, KIR2DL4 antikoerper, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 antikoerper, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 antikoerper, KIR2DL4 antikoerper
Hintergrund
CD158 Molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs, with long cytoplasmic domains, contain ITIMs and possess inhibitory functions and others, with short cytoplasmic regions, lack ITIM and have activation functions. Fourteen polymorphic KIR genes have been reported in humans. KIR2DL4 (CD158d) is a unique receptor which has an ITIM in its cytoplasmic domain and a charged residue in the transmembrane domain. It possesses both inhibitory and activation functions. Two common alleles (10A and 9A) of KIR2DL4 have been reported. The 10A allele (with 10 adenines at the end of the transmembrane exon) receptor is expressed on CD56high NK subset, whereas its expression on CD56dim NK cells is inducible upon culture. The major 9A allele receptor is a secreted form. HLA-G is the ligand of CD158d.