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Raet1d Antikörper (PE)

Raet1d Reaktivität: Maus FACS Wirt: Maus Monoclonal Charlotte d1-23 PE
Produktnummer ABIN2663873
  • Target
    Raet1d (Retinoic Acid Early Transcript delta (Raet1d))
    Reaktivität
    Maus
    Wirt
    Maus
    Klonalität
    Monoklonal
    Konjugat
    Dieser Raet1d Antikörper ist konjugiert mit PE
    Applikation
    Flow Cytometry (FACS)
    Aufreinigung
    The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
    Klon
    Charlotte d1-23
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.2 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Protect from prolonged exposure to light. Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    Raet1d (Retinoic Acid Early Transcript delta (Raet1d))
    Andere Bezeichnung
    RAE-1delta
    Synonyme
    RAE-1delta antikoerper, retinoic acid early transcript delta antikoerper, Raet1d antikoerper
    Hintergrund
    RAE-1δ is one of the five RAE-1 family, GPI-linked membrane protein consisting of alpha, beta, gamma, delta, and epsilon. They are strong homology within the family, related by 92 % -95 % sequence identity. They are distantly related to MHC class I proteins. RAE-1 proteins are abundantly expressed in fetal tissues, but not in normal adult tissue. They are constitutively expressed on some tumors and can be induced by retinoid acid. Its ligand NKG2D is found on NK cells, many transformed cell lines, and LPS-stimulated peritoneal macrophages. The interaction of NKG2D with RAE-1 transmits stimulatory signals to NK cells and other hematopoietic cells, leading to enhanced proliferation, cytokine secretion and target killing. They are involved in the regulation of innate and immune cytotoxic responses to tumors, pathogen-infected cells, and autoimmune diseases.
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