CCR4 Antikörper

Produktnummer ABIN2664335

Produktdetails anti-CCR4 Antikörper

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCR4 Antikörper ist unkonjugiert

Applikation: Intracellular Flow Cytometry (ICFC)

Kreuzreaktivität: Cynomolgus

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: L291H4

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CCR4

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Andere Bezeichnung: CD194 (CCR4 Produkte)

Synonyme: CC-CKR-4 antikoerper, CD194 antikoerper, CKR4 antikoerper, CMKBR4 antikoerper, ChemR13 antikoerper, HGCN:14099 antikoerper, K5-5 antikoerper, Ccr4 antikoerper, C-C CKR-4 antikoerper, CHEMR1 antikoerper, Cmkbr4 antikoerper, LESTR antikoerper, Sdf1r antikoerper, C-C motif chemokine receptor 4 antikoerper, chemokine (C-C motif) receptor 4 antikoerper, CCR4 antikoerper, Ccr4 antikoerper

Hintergrund: CD194, also known as CCR4, is a CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are regulated differently during Th2 development. Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4- Tregs require CD3-mediated activation to acquire a regulatory activity. Depletion of CCR4+ T cells leads to Th1-type polarization of CD4+ T cells and augmentation of CD8+ T cell responses to tumor antigens. CCR4 and its ligands are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.