lib antikoerper, GPV antikoerper, PLGPV antikoerper, CD42d antikoerper, glycoprotein V platelet L homeolog antikoerper, glycoprotein V platelet antikoerper, glycoprotein 5 (platelet) antikoerper, glycoprotein V (platelet) antikoerper, gp5.L antikoerper, GP5 antikoerper, Gp5 antikoerper
Hintergrund
CD42d is an 83 kD surface glycoprotein that non-covalently associates with GPIb and GPIX to form a receptor complex for von Willebrand factor on megakaryocytes and resting platelets. Binding sites for von Willebrand factor and thrombin have been localized to the GPIba chain of the GPI-b-V-IX complex. Platelet activation with thrombin cleaves the GPI-b-V-IX complex to release a 69 kD soluble fragment. Presence of the GPI-b-V-IX complex is important in Bernard-Soulier syndrome, a rare bleeding disorder.