DDX3X Antikörper

Produktnummer ABIN2664926

Produktdetails anti-DDX3X Antikörper

Target: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DDX3X Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: 15D1B11

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu DDX3X

Target: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Andere Bezeichnung: DDX3X (DDX3X Produkte)

Synonyme: DBX antikoerper, DDX14 antikoerper, DDX3 antikoerper, HLP2 antikoerper, D1Pas1-rs2 antikoerper, Ddx3 antikoerper, Fin14 antikoerper, An3 antikoerper, pl10 antikoerper, DDX3X antikoerper, DEAD-box helicase 3, X-linked antikoerper, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked antikoerper, DEAD-box helicase 3, X-linked L homeolog antikoerper, DDX3X antikoerper, Ddx3x antikoerper, ddx3x.L antikoerper, ddx3x antikoerper

Hintergrund: DDX3X belongs to the DEAD (Asp-Glu-Ala-Asp)-box protein family of RNA helicases, involved in the alteration of RNA secondary structure required for transcription, mRNA processing, and translation initiation. DDX3X is an essential host factor during virus infection. DDX3X serves as the cellular target of Hepatitis C virus (HCV) core protein, and also facilitates nuclear export of immature HIV RNA. The RNA helicase activity of DDX3X is required for the replication of both HCV and HIV. DDX3X is implied to act as a viral RNA sensor, mediating antiviral innate immune signaling. DDX3 participates in IκB kinase ε (IKKε) and TANK-binding kinase 1 (TBK1) dependent IRF3 activation, leading to the production of Type I interferon. DDX3X was also proposed to have antiapoptotic functions and participate in tumorigenesis.

Pathways: Ribonucleoprotein Complex Subunit Organization, Positive Regulation of Endopeptidase Activity, Negative Regulation of intrinsic apoptotic Signaling, Ribosome Assembly