ISM1 Antikörper

Produktnummer ABIN2665209

Produktdetails anti-ISM1 Antikörper

Target: ISM1 (Isthmin 1 (ISM1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser ISM1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: B054B6

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu ISM1

Target: ISM1 (Isthmin 1 (ISM1))

Andere Bezeichnung: Isthmin-1 (ISM1 Produkte)

Synonyme: 5430433G21Rik antikoerper, Ism antikoerper, C20orf82 antikoerper, ISM antikoerper, Isthmin antikoerper, bA149I18.1 antikoerper, dJ1077I2.1 antikoerper, ism antikoerper, xIsm antikoerper, isthmin 1 antikoerper, isthmin 1, angiogenesis inhibitor antikoerper, isthmin 1, angiogenesis inhibitor L homeolog antikoerper, ism1 antikoerper, Ism1 antikoerper, ISM1 antikoerper, ism1.L antikoerper

Hintergrund: Isthmin is a secreted protein, and it was initially identified in the Xenopus midbrain-hindbrain organizer (MHB) or isthmus organizer, where it is highly expressed. The MHB is an important signaling center in vertebrates and regulates the polarized morphological differentiation of the adjacent tectum and cerebellum. Mouse Isthmin is a 454 amino acid protein containing a Thrombospondin Type 1 Repeat (TSR) domain in the central region and an Adhesion-associated domain in MUC4 and Other Proteins (AMOP) domain at the C-terminal. The TSR domains are highly conserved with 98 % identity between mouse and human, 87-88 % identity between mouse and Xenopus. The C-terminal AMOP domains are also highly conserved with 99 % identity between mouse and human, 91 % identity between mouse and Xenopus. Mouse isthmin nucleotide sequence is similar to the human chromosome 20 open reading frame 82 (C20orf82). The Ism1 gene is conserved in human, chimpanzee, dog, cow, chicken, and zebrafish. Isthmin has angiostatic activity in vitro and in vivo. Isthmin inhibits EC capillary network formation mainly by interfering with the early stages of in vitro angiogenesis on matrigel. Isthmin inhibits VEGF-induced EC proliferation and induces apoptosis in the presence of VEGF. Overexpression of isthmin in B16 melanoma inhibits tumor growth and tumor angiogenesis in mice. Knockdown of isthmin in zebrafish embryos leads to abnormal intersegmental vessel (ISV) formation in the trunk.