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MTOR Antikörper
mTOR
Reaktivität: Human
FACS
Wirt: Maus
Monoclonal
6H9B10
unconjugated
Produktnummer ABIN2665281
Produktdetails anti-MTOR Antikörper
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Target
Alle MTOR (mTOR) Antikörper anzeigen
MTOR (mTOR)
(Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
Reaktivität
Alle Reaktivitäten für MTOR Antikörper
Human
Wirt
Alle Wirte für MTOR Antikörper
Maus
Klonalität
Alle Klonalitäten für MTOR Antikörper
Monoklonal
Konjugat
Alle Konjugate für MTOR Antikörper
Dieser MTOR Antikörper ist unkonjugiert
Applikation
Alle Applikationen für MTOR Antikörper
Flow Cytometry (FACS)
Kreuzreaktivität
Maus
Kreuzreaktivität (Details)
weakly cross-reactive with mouse
Aufreinigung
The antibody was purified by affinity chromatography.
Klon
6H9B10
Isotyp
IgG1 kappa
Top Product
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Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0.5 mg/mL
Buffer
phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
The antibody solution should be stored undiluted between 2°C and 8°C.
Details zu MTOR
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Target
MTOR (mTOR)
(Mechanistic Target of Rapamycin (serine/threonine Kinase) (mTOR))
Andere Bezeichnung
mTOR (mTOR Produkte )
Synonyme
FRAP1 antikoerper, FRAP antikoerper, FRAP2 antikoerper, RAFT1 antikoerper, RAPT1 antikoerper, 2610315D21Rik antikoerper, AI327068 antikoerper, Frap1 antikoerper, flat antikoerper, frap1 antikoerper, tor antikoerper, wu:fc22h08 antikoerper, mechanistic target of rapamycin kinase antikoerper, mechanistic target of rapamycin antikoerper, mechanistic target of rapamycin (serine/threonine kinase) antikoerper, MTOR antikoerper, Mtor antikoerper, mtor antikoerper
Hintergrund
MTOR (mammalian target of rapamycin) is a 289 kD member of the PI3 kinase family, containing HEAT, FRB, and FATC domains. mTOR is expressed in the nucleus and cytoplasm, and is a target for cell-cycle arrest and the immunosuppressive effects of FKBP12-rapamycin complex. mTOR controls ribosome biogenesis and cell growth, and acts as an ATP sensor. mTOR is repressed by nutrient deprivation and mitochondrial uncoupling. mTOR is the target of PI3K-regulated protein kinase, AKT/PKB (phosphorylated at Thr 2446 and Ser2448). mTOR has also been shown to bind RAPTOR, which negatively regulates mTOR kinase activity, and is also inhibited by tuberin-hamartin tumor suppressor complex. The binding of RAPTOR to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70-alpha.
Pathways
PI3K-Akt Signalweg , RTK Signalweg , AMPK Signaling , Interferon-gamma Pathway , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Regulation of Actin Filament Polymerization , Regulation of Muscle Cell Differentiation , Regulation of Cell Size , Skeletal Muscle Fiber Development , Regulation of Carbohydrate Metabolic Process , Autophagie , CXCR4-mediated Signaling Events , BCR Signaling , Warburg Effekt
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