Plexin B2 Antikörper

Produktnummer ABIN2665329

Produktdetails anti-Plexin B2 Antikörper

Target: Plexin B2 (PLXNB2)

Reaktivität: Maus

Wirt: Armenischer Hamster

Klonalität: Monoklonal

Konjugat: Dieser Plexin B2 Antikörper ist unkonjugiert

Applikation: Intracellular Flow Cytometry (ICFC)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: 3E7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu Plexin B2

Target: Plexin B2 (PLXNB2)

Andere Bezeichnung: Plexin B2 (PLXNB2 Produkte)

Synonyme: PLXNB2 antikoerper, MM1 antikoerper, Nbla00445 antikoerper, PLEXB2 antikoerper, dJ402G11.3 antikoerper, 1110007H23Rik antikoerper, Debt antikoerper, mKIAA0315 antikoerper, plexin B2 antikoerper, plexin B2 S homeolog antikoerper, PLXNB2 antikoerper, plxnb2.S antikoerper, plxnb2 antikoerper, Plxnb2 antikoerper

Hintergrund: Plexin B2 is a 240 kD transmembrane receptor belonging to the semaphorin receptor family, B subfamily. All the family members share an extracellular semaphorin domain and an intracellular plexin domain-containing tail that can mediate intracellular signaling. Distinct from the other subfamily members, Plexin B2 contains an intracellular domain with a PDZ motif (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (DlgA), and zonula occludens-1 protein (zo-1)), which can relay extracellular signals to intracellular motifs. Similar to the other B family members, Plexin B2 was also originally found in the nervous system and was later reported on endocrine, reproductive, urinary, digestive, respiratory, and immune systems. In immune cells, Plexin B2 is highly expressed on macrophages, conventional dendritic cells (cDCs), and plasmacytoid dendritic cells (pDCs). It is also expressed on T cells and T-dependent germinal center B cells. Plexin B2 facilitates ligand induced cell guidance and migration in the nervous system, and induces cytoskeletal changes in overexpression assays through RhoGTPase. However, the function of Plexin B2 in the immune system is not conclusive. Plexin B2 has been reported to modulate upon activation of DCs by TLR ligands, TNF-α, and anti-CD40. It also functions as a negative regulator of Rac and Cdc42 and modulates cell motility in macrophages. Plexin B2 has been found to have several semaphorin ligands including Semaphorin-3E, Semaphorin-4A, Semaphorin-4C, and Semaphorin-4D.

Pathways: Tube Formation