LAT Antikörper
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- Target Alle LAT Antikörper anzeigen
- LAT (Linker For Activation of T Cells (LAT))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser LAT Antikörper ist unkonjugiert
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Applikation
- Biochemical Assay (BCA)
- Keine Kreuzreaktivität
- Maus
- Aufreinigung
- The antibody was purified by affinity chromatography.
- Klon
- LAT1111
- Isotyp
- IgG1
- Top Product
- Discover our top product LAT Primärantikörper
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anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibody
LAT Reaktivität: Human WB, IP, FACS Wirt: Maus Monoclonal LAT-01 unconjugated
anti-Linker For Activation of T Cells (LAT) antibodyLAT Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr191) antibodyLAT Reaktivität: Human WB, ELISA, IHC, IP, IF Wirt: Kaninchen Monoclonal 2E4 unconjugated Recombinant Antibody
anti-Linker For Activation of T Cells (LAT) (pTyr226) antibodyLAT Reaktivität: Human WB, IHC (f) Wirt: Maus Monoclonal J96-1238-58-93 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 1-233) antibodyLAT Reaktivität: Human WB, ELISA, IHC (p) Wirt: Maus Monoclonal 3B11-1D5 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 30-237) antibodyLAT Reaktivität: Maus WB, IHC, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr161) antibodyLAT Reaktivität: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibodyLAT Reaktivität: Human WB, IHC, IP, IHC (p) Wirt: Maus Monoclonal LAT1111 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 25-221) antibodyLAT Reaktivität: Human WB, IHC, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 33-227) antibodyLAT Reaktivität: Ratte WB, IHC, ICC Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Upon receipt, store between 2°C and 8°C.
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- Target
- LAT (Linker For Activation of T Cells (LAT))
- Andere Bezeichnung
- LAT (LAT Produkte)
- Synonyme
- LAT antikoerper, lat antikoerper, LAT1 antikoerper, pp36 antikoerper, linker for activation of T-cells antikoerper, linker for activation of T cells antikoerper, LAT antikoerper, lat antikoerper, Lat antikoerper
- Hintergrund
- LAT (linker for activation of T-cells) is a 36 kD phospho-tyrosine adaptor protein containing SH2 domains and a CVRC motif. Two LAT isoforms have been reported with approximate molecular weights of 36 kD and 38 kD. LAT is localized to lipid rafts, and is also a potential type III transmembrane protein, thought to be expressed in the juxtanuclear intracellular compartment. LAT links TCR engagement to Ras-MAPK activation, Ca2+ flux, IL-2 expression and is required for T-cell development. LAT is phosphorylated when activated by TCR cross-linking, where it recruits signaling molecules. LAT activation can be prevented by polyunsaturated fatty acids. LAT is modified by ZAP-70 and Syk phosphorylation and can also be palmitoylated. LAT has been reported to be associated with Grb2, Gads, Grap, PLC-γ1, p85 subunit PI3K, ZAP-70, Syk, Itk, Vav, SLP-76, and cbl.
- Pathways
- T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
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