NLRP2 Antikörper

Produktnummer ABIN2666255

Produktdetails anti-NLRP2 Antikörper

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NLRP2 Antikörper ist unkonjugiert

Applikation: Functional Studies (Func), Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: 8F10B51

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Upon receipt, store undiluted at 4°C

Details zu NLRP2

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Andere Bezeichnung: NLRP2 (NLRP2 Produkte)

Synonyme: CLR19.9 antikoerper, NALP2 antikoerper, NBS1 antikoerper, PAN1 antikoerper, PYPAF2 antikoerper, NLRP2 antikoerper, E330007A02Rik antikoerper, Nalp2 antikoerper, NLR family pyrin domain containing 2 antikoerper, NACHT, LRR and PYD domains-containing protein 2 antikoerper, NLR family pyrin domain containing 7 antikoerper, NLR family, pyrin domain containing 2 antikoerper, NLRP2 antikoerper, LOC100301026 antikoerper, LOC100387349 antikoerper, NLRP7 antikoerper, Nlrp2 antikoerper

Hintergrund: NLRP2, also known as NALP2 or PAN1, is a member of the pyrin domain-containing NLR protein (NLRP) family. The NLR proteins interact with ASC via the conserved pyrin domain, which results in the activation of caspase-1 and maturation of the pro-inflammatory cytokines IL-1β and IL-18. NLRP2 is also involved in the formation of the inflammasome and caspase-1 activation. NLRP2 negatively regulates NFκB activation, which is induced by TNF-α, through inhibiting NFKBIA degradation. In addition, NLRP2 is one of the maternal effect genes and plays a crucial role in embryonic development. In mouse embryos, knockdown or mutation of NLRP2 leads to developmental defections. Truncation of the NLRP2 gene is reported to associate with an overgrowth discorder called Beckwith-Wiedemann Syndrome.

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome