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NLRP2 Antikörper

NLRP2 Reaktivität: Human Func, FACS Wirt: Maus Monoclonal 8F10B51 unconjugated
Produktnummer ABIN2666255
  • Target Alle NLRP2 Antikörper anzeigen
    NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))
    Reaktivität
    • 33
    • 10
    • 6
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 25
    • 6
    • 2
    • 1
    Maus
    Klonalität
    • 29
    • 5
    Monoklonal
    Konjugat
    • 34
    Dieser NLRP2 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 10
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Functional Studies (Func), Flow Cytometry (FACS)
    Aufreinigung
    The antibody was purified by affinity chromatography.
    Klon
    8F10B51
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product NLRP2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Upon receipt, store undiluted at 4°C
  • Target
    NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))
    Andere Bezeichnung
    NLRP2 (NLRP2 Produkte)
    Synonyme
    CLR19.9 antikoerper, NALP2 antikoerper, NBS1 antikoerper, PAN1 antikoerper, PYPAF2 antikoerper, NLRP2 antikoerper, E330007A02Rik antikoerper, Nalp2 antikoerper, NLR family pyrin domain containing 2 antikoerper, NACHT, LRR and PYD domains-containing protein 2 antikoerper, NLR family pyrin domain containing 7 antikoerper, NLR family, pyrin domain containing 2 antikoerper, NLRP2 antikoerper, LOC100301026 antikoerper, LOC100387349 antikoerper, NLRP7 antikoerper, Nlrp2 antikoerper
    Hintergrund
    NLRP2, also known as NALP2 or PAN1, is a member of the pyrin domain-containing NLR protein (NLRP) family. The NLR proteins interact with ASC via the conserved pyrin domain, which results in the activation of caspase-1 and maturation of the pro-inflammatory cytokines IL-1β and IL-18. NLRP2 is also involved in the formation of the inflammasome and caspase-1 activation. NLRP2 negatively regulates NFκB activation, which is induced by TNF-α, through inhibiting NFKBIA degradation. In addition, NLRP2 is one of the maternal effect genes and plays a crucial role in embryonic development. In mouse embryos, knockdown or mutation of NLRP2 leads to developmental defections. Truncation of the NLRP2 gene is reported to associate with an overgrowth discorder called Beckwith-Wiedemann Syndrome.
    Pathways
    Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
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